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1. (WO2003084961) 1- OR 3-THIA-BENZONAPHTHOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF

Pub. No.:    WO/2003/084961    International Application No.:    PCT/HR2003/000014
Publication Date: Fri Oct 17 01:59:59 CEST 2003 International Filing Date: Thu Apr 10 01:59:59 CEST 2003
IPC: C07D 333/80
C07D 495/04
Applicants: PLIVA-ISTRAZIVACKI INSTITUT d.o.o.
MERCEP, Mladen
MESIC, Milan
PESIC, Dijana
OZIMEC, Ivana
TROJKO, Rudolf
Inventors: MERCEP, Mladen
MESIC, Milan
PESIC, Dijana
OZIMEC, Ivana
TROJKO, Rudolf
Title: 1- OR 3-THIA-BENZONAPHTHOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF
Abstract:
The present invention relates to 1- or 3-thiabenzonaphthoazulene derivatives to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the inhibition of tumour necrosis factor-alpha (TNF-alpha) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.