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1. (WO2003084961) 1- OR 3-THIA-BENZONAPHTHOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/084961    International Application No.:    PCT/HR2003/000014
Publication Date: 16.10.2003 International Filing Date: 09.04.2003
Chapter 2 Demand Filed:    30.10.2003    
IPC:
C07D 333/80 (2006.01), C07D 495/04 (2006.01)
Applicants: PLIVA-ISTRAZIVACKI INSTITUT d.o.o. [HR/HR]; Prilaz baruna Filipovica 29, 10000 Zagreb (HR) (For All Designated States Except US).
MERCEP, Mladen [HR/HR]; (HR) (For US Only).
MESIC, Milan [HR/HR]; (HR) (For US Only).
PESIC, Dijana [HR/HR]; (HR) (For US Only).
OZIMEC, Ivana [HR/HR]; (HR) (For US Only).
TROJKO, Rudolf [HR/HR]; (HR) (For US Only)
Inventors: MERCEP, Mladen; (HR).
MESIC, Milan; (HR).
PESIC, Dijana; (HR).
OZIMEC, Ivana; (HR).
TROJKO, Rudolf; (HR)
Priority Data:
P020303A 10.04.2002 HR
Title (EN) 1- OR 3-THIA-BENZONAPHTHOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF
(FR) 1- OU 3-THIA-BENZONAPHTHOAZULENES UTILISES COMME INHIBITEURS DE PRODUCTION DU FACTEUR DE NECROSE ET INTERMEDIAIRES DESTINES A LA PREPARATION DE CEUX-CI
Abstract: front page image
(EN)The present invention relates to 1- or 3-thiabenzonaphthoazulene derivatives to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the inhibition of tumour necrosis factor-alpha (TNF-alpha) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.
(FR)La présente invention concerne les dérivés de 1- or 3-thiabenzonaphthoazulène, leurs sels et solvates pharmaceutiquement acceptables, des processus et des intermédiaires de préparation correspondants et leurs effets anti-inflammatoires et notamment l'inhibition de la production du facteur alpha de nécrose tumorale (TNF-alpha) ainsi que l'inhibition de la production d'interleukine-1 (IL-1), de même que leur action analgésique.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)