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1. (WO2003078583) OPTIMIZATION OF CROSSOVER POINTS FOR DIRECTED EVOLUTION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/078583    International Application No.:    PCT/US2003/007610
Publication Date: 25.09.2003 International Filing Date: 10.03.2003
Chapter 2 Demand Filed:    07.10.2003    
IPC:
G06N 3/00 (2006.01), C12Q 1/68 (2006.01), C40B 50/02 (2006.01), G01N 33/48 (2006.01), G01N 33/50 (2006.01), G01N 33/53 (2006.01), G06F 17/00 (2006.01), G06F 17/10 (2006.01), G06F 17/11 (2006.01), G06F 19/22 (2011.01), G06F 19/16 (2011.01)
Applicants: MAXYGEN, INC. [US/US]; 515 Galveston Drive, Redwood City, CA 95063 (US) (For All Designated States Except US).
MUNDORFF, Emily, C. [US/US]; (US) (For All Designated States Except US).
GOVINDARAJAN, Sridhar [IN/US]; (US) (For US Only).
GUSTAFSSON, Claes [SE/US]; (US) (For US Only).
MINSHULL, Jeremy, S. [GB/US]; (US) (For US Only)
Inventors: GOVINDARAJAN, Sridhar; (US).
GUSTAFSSON, Claes; (US).
MINSHULL, Jeremy, S.; (US)
Agent: WEAVER, Jeffrey, K.; BEYER WEAVER & THOMAS, LLP, P.O. Box 778, Berkeley, CA 94704-0778 (US)
Priority Data:
60/363,505 09.03.2002 US
60/373,591 18.04.2002 US
Title (EN) OPTIMIZATION OF CROSSOVER POINTS FOR DIRECTED EVOLUTION
(FR) OPTIMISATION DE POINTS DE CROISEMENT A DES FINS D'EVOLUTION DIRIGEE
Abstract: front page image
(EN)Methods and devices for more efficiently engineering diversity into recombinant polypeptides and/or nucleic acids are provided herein. For example, a variety of methods of selecting and/or assessing potential crossover sites in an amino acid sequence or a nucleotide sequence are provided, as well as the resulting chimeric product sequences. These methods include, e.g., consideration of structural, functional and/or statistical data in the selection and assessment of sequences and crossover sites for use in recombination.
(FR)Procédés et dispositifs permettant une mise au point génétique plus efficace de la diversité dans la recombinaison de polypeptides et/ou d'acides nucléiques. L'invention se réfère par exemple à divers procédés de sélection et/ou d'évaluation de sites de croisement potentiels dans une séquence d'acides aminés ou une séquence nucléotidique, et aux séquences de produits chimères obtenues. Ces procédés comprennent par exemple la prise en compte de données structurales, fonctionnelles et/ou statistiques dans la sélection et l'évaluation de séquences et de sites de croisement à des fins de recombinaison.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)