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1. (WO2003078453) MUTANTS OF THE P4 PROTEIN OF NONTYPABLE HAEMOPHILUS INFLUENZAE WITH REDUCED ENZYMATIC ACTIVITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/078453    International Application No.:    PCT/US2003/007895
Publication Date: 25.09.2003 International Filing Date: 13.03.2003
Chapter 2 Demand Filed:    09.10.2003    
IPC:
A61K 38/00 (2006.01), A61K 39/00 (2006.01), A61K 39/102 (2006.01), C07K 14/285 (2006.01), C07K 16/12 (2006.01)
Applicants: WYETH HOLDINGS CORPORATION [US/US]; Five Giralda Farms, Madison, NJ 07940 (US) (For All Designated States Except US).
THE CURATORS OF THE UNIVERSITY OF MISSOURI [US/US]; 316 University Hall, Columbia, MO 65211 (US) (For All Designated States Except US).
GREEN, Bruce, A. [US/US]; (US) (For US Only).
ZLOTNICK, Gary, W. [US/US]; (US) (For US Only).
FLETCHER, Leah, D. [US/US]; (US) (For US Only).
SMITH, Arnold, L. [US/US]; (US) (For US Only).
REILLY, Thomas, J. [US/US]; (US) (For US Only)
Inventors: GREEN, Bruce, A.; (US).
ZLOTNICK, Gary, W.; (US).
FLETCHER, Leah, D.; (US).
SMITH, Arnold, L.; (US).
REILLY, Thomas, J.; (US)
Agent: BAK, Mary, E.; Howson and Howson, Spring House Corporate Center, P.O. Box 457, Spring House, PA 19477 (US)
Priority Data:
60/364,688 15.03.2002 US
Title (EN) MUTANTS OF THE P4 PROTEIN OF NONTYPABLE HAEMOPHILUS INFLUENZAE WITH REDUCED ENZYMATIC ACTIVITY
(FR) MUTANTS DE LA PROTEINE P4 DE HAEMOPHILUS INFLUENZAE NON TYPABLE A ACTIVITE ENZYMATIQUE REDUITE
Abstract: front page image
(EN)A P4 variant protein that has reduced enzymatic activity and that induces antibody to wild-type P4 protein and/or has good bactericidal activity against non-typable H. influenzae (NTHi) is useful as an active component in an immunogenic composition for humans. Methods of using these proteins, and compositions containing them in combination with additional antigens, are also provided.
(FR)L'invention concerne un variant de la protéine P4 qui présente une activité enzymatique réduite et qui induit la production d'anticorps dirigés contre la protéine P4 de type sauvage et/ou qui présente une bonne activité bactéricide contre H. influenzae non typable (NTHi) et qui peut être utilisé comme ingrédient actif dans une composition immunogène destinée aux humains. L'invention concerne également des méthodes d'utilisation de ces protéines, des compositions renfermant ces protéines, ainsi que des antigènes supplémentaires.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)