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Pub. No.:    WO/2003/077953    International Application No.:    PCT/GB2003/001035
Publication Date: 25.09.2003 International Filing Date: 12.03.2003
Chapter 2 Demand Filed:    13.10.2003    
A61K 47/48 (2006.01)
Applicants: PHAGE GENOMICS INC. [US/GB]; P.O. Box 27740, Las Vegas, NV 89126 (US) (For All Designated States Except US).
WEST, David [GB/GB]; (GB) (For US Only).
POLYANSKAYA, Natasha [GB/GB]; (GB) (For US Only)
Inventors: WEST, David; (GB).
PASECHNIK, Vladimir;
Agent: WALES, Alice, Irene; fj Cleveland, 40-43 Chancery Lane, London WC2A 1JQ (GB)
Priority Data:
0205786.7 12.03.2002 GB
Abstract: front page image
(EN)The present invention provides a composition which comprises a complex of a bacteriophage and a cationic delivery moiety, such as a cationic polymer, in particular a cationic peptoid or a cationic peptide. More specifically, the present invention provides a composition comprising a complex of a bacteriophage and a delivery peptide or a protective or stabilising peptide. The present invention further provides a method for the delivery of bacteriophage across a membrane, such as a cell membrane; and a method for the treatment of bacterial infection, in particular intracellular bacterial infection, using a complex according to the invention.
(FR)L'invention concerne une composition comprenant un complexe d'un bactériophage et d'un fragment cationique de distribution, de type polymère cationique, en particulier peptoïde cationique ou peptide cationique. Plus particulièrement, l'invention concerne une composition comprenant un complexe d'un bactériophage et d'un peptide de distribution ou d'un peptide protecteur ou stabilisateur. L'invention concerne en outre une méthode d'administration dudit bactériophage sur toute la surface d'une membrane, de type membrane cellulaire; et une méthode de traitement d'infection bactérienne, en particulier d'infection bactérienne intracellulaire, mettant en oeuvre un complexe de l'invention.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)