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Machine translation
1. (WO2003077872) CELL SURFACE TROPOMYOSIN AS A TARGET OF ANGIOGENESIS INHIBITION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/077872    International Application No.:    PCT/US2003/008060
Publication Date: 25.09.2003 International Filing Date: 17.03.2003
IPC:
C07K 4/12 (2006.01), C07K 2/00 (2006.01), G01N 33/53 (2006.01), G01N 33/536 (2006.01)
Applicants: ATTENUON, LLC [US/US]; 10130 Sorrento Valley Road, Suite B, San Diego, CA 92121 (US) (For All Designated States Except US).
McCRAE, Keith [US/US]; (US) (For US Only).
DONATE, Fernando [ES/US]; (US) (For US Only).
JUAREZ, Jose [US/US]; (US) (For US Only).
MAZAR, Andrew, P. [US/US]; (US) (For US Only)
Inventors: McCRAE, Keith; (US).
DONATE, Fernando; (US).
JUAREZ, Jose; (US).
MAZAR, Andrew, P.; (US)
Agent: LIVNAT, Shmuel; Venable, Baetjer, Howard & Civiletti, LLP, 1201 New York Avenue, NW, Suite 1000, Washington, DC 20005-3917 (US)
Priority Data:
60/364,047 15.03.2002 US
Title (EN) CELL SURFACE TROPOMYOSIN AS A TARGET OF ANGIOGENESIS INHIBITION
(FR) TROPOMYOSINE DE SURFACE CELLULAIRE SERVANT DE CIBLE DE L'INHIBITION DE L'ANGIOGENESE
Abstract: front page image
(EN)The present invention is directed to novel methods for inhibiting angiogenesis and treating tumors and cancer by targeting tropomyosin (Tpm) expressed on the surface of endothelial cells and/or tumor cells, to Tpm polypeptides and peptides, as well as variants and derivatives thereof that bind inhibitors of angiogenesis, and to anti-Tpm antibodies that block or stimulate angiogenesis. Cyclic peptides that bind to the D5 subunit of HK¿a? and inhibit angiogenesis are also included. Method for screening test compounds as candidate antiangiogenic molecule that binds to Tpm are disclosed, as are affinity ligands comprising the proteins, peptides, variants and derivatives of the invention.
(FR)La présente invention concerne de nouveaux procédés d'inhibition de l'angiogenèse et de traitement de tumeurs et de cancers par ciblage de tropomyosine (Tpm) exprimée à la surface de cellules endothéliales et/ou tumorales. L'invention concerne également des polypeptides et peptides de tropomyosine, des variants et dérivés de ces polypeptides et peptides liant des inhibiteurs de l'angiogenèse, ainsi que des anticorps anti-tropomyosine bloquant ou stimulant l'angiogenèse. L'invention concerne par ailleurs des peptides cycliques se liant à la sous-unité D5 de HKa et inhibant l'angiogenèse. L'invention concerne finalement un procédé de criblage de composés test en tant que molécule anti-angiogénique candidate se liant à tropomyosine, et des ligands par affinité contenant les protéines, peptides, variants et dérivés selon l'invention.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)