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1. (WO2003077852) CARTILAGE REGENERATION USING CHONDROCYTE AND TGF-&bgr;
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/077852    International Application No.:    PCT/US2003/007486
Publication Date: 25.09.2003 International Filing Date: 12.03.2003
IPC:
A61K 38/18 (2006.01), A61K 48/00 (2006.01), C12N 5/06 (2006.01), C12N 5/16 (2006.01)
Applicants: TISSUEGENE, INC. [US/US]; 209 Perry Parkway, Suite 13, Gaithersburg, MD 20877 (US) (For All Designated States Except US).
SONG, Sun Uk [US/KR]; (KR) (For US Only).
YI, Youngsuk [KR/US]; (US) (For US Only).
LEE, Kwan Hee [KR/US]; (US) (For US Only).
NOH, Moon Jong [KR/US]; (US) (For US Only).
LEE, Dug Keun [KR/US]; (US) (For US Only)
Inventors: SONG, Sun Uk; (KR).
YI, Youngsuk; (US).
LEE, Kwan Hee; (US).
NOH, Moon Jong; (US).
LEE, Dug Keun; (US)
Agent: JHK, Law; P.O. Box 1078, La Canada, CA 91012-1078 (US)
Priority Data:
60/363,764 12.03.2002 US
Title (EN) CARTILAGE REGENERATION USING CHONDROCYTE AND TGF-&bgr;
(FR) REGENERATION DE CARTILAGES A L'AIDE DE CHONDROCYTES ET DE TGF-$G(B)
Abstract: front page image
(EN)The present application is directed to a method of treating osteoarthritis, which includes obtaining a member of a transforming growth factor superfamily of proteins; obtaining a population of cultured connective tissue cells that may contain vector encoding a gene, or a population of cultured connective tissue cells that do not contain any vector encoding a gene; and then transferring the protein and the connective tissue cells into an arthritic joint space of a mammalian host, such that the activity of the combination within the joint space results in regenerating connective tissue.
(FR)L'invention porte sur un procédé de traitement de l'ostéoarthtose consistant: à obtenir une protéine membre de la superfamille des facteurs de croissance transformants; à obtenir une population de cellules de tissus conjonctifs de culture pouvant contenir un vecteur codant pour un gène ou une population de cellules de tissus conjonctifs de culture ne contenant aucun vecteur codant pour un gène; puis à transférer les protéines et les tissus conjonctifs dans l'espace d'une articulation arthritique de mammifère pour que l'activité de la combinaison y produise une regénération des tissus conjonctifs.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)