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1. (WO2003077652) METHOD FOR TREATING DIABETIC ULCERS

Pub. No.:    WO/2003/077652    International Application No.:    PCT/US2003/007810
Publication Date: Sep 25, 2003 International Filing Date: Mar 12, 2003
IPC: A61K 38/18
Applicants: BREM, Harold
Inventors: BREM, Harold
Title: METHOD FOR TREATING DIABETIC ULCERS
Abstract:
A method and means have been developed to deliver a therapeutic dose or dosages of the angiogenic molecule, Vascular Endothelial Growth Factor (VEGF) that results in a statically significant decrease in the time to achieve 100% wound closure and accelerates the rate of healing in experimental diabetic ulcers. Toxicity is evaluated by measuring any local inflammatory response at the wound site, the systemic absorption of VEGF, and the effect on distant organs that may be particularly susceptible to VEGF therapy (e.g., retinopathy and hepatitis) The angiogenic response is quantified by measuring the change in collagen deposition, epithelialization, and the closure rates of diabetic ulcers after therapeutic dosing with ADV-VEGF. Sustained administration of VEGF stimulates and accelerates the healing process as evidenced by a reduced time to complete healing (defined by 100% epithelialization and no drainage) in experimental diabetic ulcers, with minimal to no toxicity. Important features of the method and reagents for use therein are that the VEGF is released into the ulcer in a sufficient quantity over a period of time for at least two to six weeks, or to closure of the wound.