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Pub. No.:    WO/2003/076901    International Application No.:    PCT/US2003/007149
Publication Date: 18.09.2003 International Filing Date: 07.03.2003
G01N 33/566 (2006.01), G01N 33/68 (2006.01)
Applicants: RIGEL PHARMACEUTICALS, INC. [US/US]; 1180 Veterans Boulevard, South San Francisco, CA 94080 (US) (For All Designated States Except US).
ANDERSON, David, C. [US/US]; (US) (For US Only).
BENNETT, Mark, K. [US/US]; (US) (For US Only).
KINSELLA, Todd, M. [US/US]; (US) (For US Only).
MASUDA, Esteban [CO/US]; (US) (For US Only)
Inventors: ANDERSON, David, C.; (US).
BENNETT, Mark, K.; (US).
KINSELLA, Todd, M.; (US).
MASUDA, Esteban; (US)
Agent: PEASE, Ann, M.; Dorsey & Whitney LLP, 4 Embarcadero Center, Suite 3400, San Francisco, CA 94111 (US)
Priority Data:
10/095,659 08.03.2002 US
Abstract: front page image
(EN)The present invention provides methods for identifying and/or rank ordering target polypeptides that interact with a candidate polypeptide. Potential targets for the candidate polypeptide are identified using an interaction assay. A set of mutants are derived from the candidate polypeptide and a functional profile is obtained for the set of mutants and the candidate polypeptide. Also, for each identified potential target, an interaction profile is obtained for the set of mutants and the candidate polypeptide. The interaction profiles are compared to the functional profile and based on the degree of correspondence between the profiles, the potential targets are identified and/or rank ordered as target polypeptides that interact to the candidate polypeptide.
(FR)L'invention porte sur des procédés d'identification ou de classement par ordre de polypeptides interagissant avec un polypeptide candidat. Les cibles potentielles du polypeptide candidat sont identifiées à l'aide d'un essai d'interaction. On produit un ensemble de mutants à partir du polypeptide candidat et on obtient un profil de fonctions pour l'ensemble des mutants, et pour le polypeptide candidat. Pour chaque cible potentielle identifiée, on obtient un profil d'interaction pour l'ensemble de mutants, et pour le polypeptide candidat. Les profils d'interaction sont comparés aux profils fonctionnels, et en fonction du degré de correspondance entre les profils on identifie les cibles potentielles et/ou leur ordre de classement comme polypeptides cibles interagissant avec le polypeptide candidat.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)