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Machine translation
1. (WO2003076462) USE OF RECOMBINANT TRYPSIN FOR VACCINE PRODUCTION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/076462    International Application No.:    PCT/NL2002/000157
Publication Date: 18.09.2003 International Filing Date: 08.03.2002
IPC:
C12N 7/00 (2006.01), C12N 9/76 (2006.01), C12N 15/82 (2006.01)
Applicants: CRUCELL HOLLAND B.V. [NL/NL]; Archimedesweg 4, NL-2333 CN Leiden (NL) (For All Designated States Except US).
PAU, Maria, Grazia [IT/NL]; (NL) (For US Only).
UYTDEHAAG, Alphonsus, Gerardus, Cornelis, Maria [NL/NL]; (NL) (For US Only)
Inventors: PAU, Maria, Grazia; (NL).
UYTDEHAAG, Alphonsus, Gerardus, Cornelis, Maria; (NL)
Agent: PRINS, A., W.; c/o Vereenigde, Nieuwe Parklaan 97, NL-2587 BN The Hague (NL)
Priority Data:
Title (EN) USE OF RECOMBINANT TRYPSIN FOR VACCINE PRODUCTION
(FR) UTILISATION DE TRYPSINE RECOMBINANTE DANS LA PRODUCTION DE VACCINS
Abstract: front page image
(EN)The present invention provides the use of recombinantly produced serine proteases, such as bovine trypsin produced in corn, for the production and propagation of viruses in vitro cell cultures and discloses methods for the production of viral batches in serum-free tissue culture, without using animal-derived trypsin.
(FR)La présente invention concerne l'utilisation de sérine protéases produites par recombinaison, telles que la trypsine bovine produite dans du maïs, pour la production et la multiplication de virus dans des cultures cellulaires in vitro. Cette invention concerne également des procédés de production de lots de virus en culture tissulaire sans sérum, sans utilisation de trypsine d'origine animale.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)