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Machine translation
1. (WO2003076455) IMMUNIZING COMPOSITION AND METHOD FOR INDUCING AN IMMUNE RESPONSE AGAINST THE SS-SECRETASE CLEAVAGE SITE OF AMYLOID PRECURSOR PROTEIN
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/076455    International Application No.:    PCT/US2003/006388
Publication Date: 18.09.2003 International Filing Date: 04.03.2003
IPC:
A61K 39/00 (2006.01), C07K 16/18 (2006.01)
Applicants: RAMOT AT TEL-AVIV UNIVERSITY LTD. [IL/IL]; P.O. Box 39296, 61392 Tel-Aviv (IL) (For All Designated States Except US).
SOLOMON, Beka [IL/IL]; (IL) (For US Only).
MCINNIS, Patricia [US/US]; (US) (SD only)
Inventors: SOLOMON, Beka; (IL)
Agent: BROWDY AND NEIMARK, P.L.L.C.; 624 Ninth Street N.W., Suite 300, Washington, DC 20001-5303 (US)
Priority Data:
60/361,344 05.03.2002 US
Title (EN) IMMUNIZING COMPOSITION AND METHOD FOR INDUCING AN IMMUNE RESPONSE AGAINST THE SS-SECRETASE CLEAVAGE SITE OF AMYLOID PRECURSOR PROTEIN
(FR) COMPOSITION IMMUNISANTE ET PROCEDE PERMETTANT D'INDUIRE UNE REPONSE IMMUNITAIRE CONTRE LE SITE DE CLIVAGE DE $G(B)-SECRETASE
Abstract: front page image
(EN)The present invention is directed to an immunizing composition containing an antigenic product such as a multiple antigen peptide system (MAPS) or a filamentous bacteriophage displaying an AßPP epitope spanning the ß-secretase cleavage site of AßPP and a method for inducing an immune response against the ß-secretase cleavage site of AßPP using this immunizing composition. The present invention is also directed to antibodies against the ß-secretase cleavage site of AßPP and their use in a method for inhibiting the formation of amyloid ß.
(FR)L'invention porte sur une composition immunisante contenant un produit antigénique tel qu'un système multiple de peptides antigènes (MAPS) ou un bactériophage filamenteux présentant un épitope A$g(b)PP qui répartit le site de clivage de ß-sécrétase, et sur un procédé d'induction de réponse immunitaire contre le site de clivage de ß-sécrétase de AßPP au moyen de cette composition immunisante. L'invention concerne aussi des anticorps contre le site de clivage de ß-sécrétase de AßPP, ainsi que leur utilisation dans l'inhibition de la formation d'amyloïdes ß.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)