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1. (WO2003075921) MONO- AND BICYCLIC AZOLE DERIVATIVES THAT INHIBIT THE INTERACTION OF LIGANDS WITH RAGE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/075921    International Application No.:    PCT/US2003/006749
Publication Date: 18.09.2003 International Filing Date: 05.03.2003
Chapter 2 Demand Filed:    22.09.2003    
IPC:
C07D 233/54 (2006.01), C07D 235/08 (2006.01), C07D 235/12 (2006.01), C07D 235/14 (2006.01), C07D 235/18 (2006.01), C07D 235/30 (2006.01), C07D 401/04 (2006.01), C07D 401/06 (2006.01), C07D 401/12 (2006.01), C07D 401/14 (2006.01), C07D 403/12 (2006.01), C07D 403/14 (2006.01), C07D 405/04 (2006.01), C07D 405/12 (2006.01), C07D 413/12 (2006.01), C07D 453/02 (2006.01)
Applicants: TRANSTECH PHARMA, INC. [US/US]; Suite 110, 4170 Mendenhall Oaks Parkway, High Point, NC 27265 (US) (For All Designated States Except US).
MJALLI, Adnan, M., M. [US/US]; (US) (For US Only).
ANDREWS, Robert, C. [US/US]; (US) (For US Only).
GOPALASWAMY, Ramesh [IN/US]; (US) (For US Only).
HARI, Anitha [AU/US]; (US) (For US Only).
AVOR, Kwasi [US/US]; (US) (For US Only).
QABAJA, Ghassan [JO/US]; (US) (For US Only).
GUO, Xiao-Chuan [CN/US]; (US) (For US Only).
GUPTA, Suparna [IN/US]; (US) (For US Only).
JONES, David, R. [US/US]; (US) (For US Only).
CHEN, Xin [CN/US]; (US) (For US Only)
Inventors: MJALLI, Adnan, M., M.; (US).
ANDREWS, Robert, C.; (US).
GOPALASWAMY, Ramesh; (US).
HARI, Anitha; (US).
AVOR, Kwasi; (US).
QABAJA, Ghassan; (US).
GUO, Xiao-Chuan; (US).
GUPTA, Suparna; (US).
JONES, David, R.; (US).
CHEN, Xin; (US)
Agent: CALKINS, Charles, W.; Kilpatrick Stockton LLP, 1001 West Fourth Street, Winston-Salem, NC 27101 (US)
Priority Data:
60/361,983 05.03.2002 US
Title (EN) MONO- AND BICYCLIC AZOLE DERIVATIVES THAT INHIBIT THE INTERACTION OF LIGANDS WITH RAGE
(FR) DERIVES DE L'AZOLE ET DERIVES BICYCLIQUES FUSIONNES DE L'AZOLE, AGENTS THERAPEUTIQUES
Abstract: front page image
(EN)This invention provides certain compounds of formula I wherein A1 is O, S or -N(R2)-, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as modulators of the interaction between the receptor for advanced glycated end products (RAGE) and its ligands, such as advanced glycated end products (AGEs), S100/calgranulin/EN-RAGE, &bgr;-amyloid and amphoterin, and for the management, treatment, control, or as an adjunct treatment for diseases in humans caused by RAGE. Such diseases or disease states include acute and chronic inflammation, the development of diabetic late complications such as increased vascular permeability, nephropathy, atherosclerosis, and retinopathy, the development of Alzheimer’s disease, erectile dysfunction, and tumor invasion and metastasis.
(FR)L'invention porte sur certains composés, leurs procédés de préparation, des préparations pharmaceutiques les contenant, et sur leur utilisation pour traiter certains états morbides de l'homme et l'animal. Lesdits composés sont des modulateurs de l'interaction entre le récepteur des produits glyqués finaux (RAGE) et son ligand, tels que des produits glyqués finaux avancés (AGE), la S100/calgranuline/EN-RAGE, la $g(b)-amyloïde, et l'amphotérine, assurant la gestion, le traitement, la maîtrise ou le traitement d'appoint de maladies de l'homme causées par le RAGE. Ces maladies et états morbides comprennent: les inflammations aiguës et chroniques; les complications tardives du diabète telles que l'accroissement de la perméabilité vasculaire, la néphropathie, l'athérosclérose, ainsi que la maladie d'Alzheimer, les troubles de l'érection, l'envahissement tumoral et les métastases.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)