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1. (WO2003075911) USE OF PPAR ALPHA AGONISTS FOR THE TREATMENT OF VASCULAR AND RENAL DISEASES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/075911    International Application No.:    PCT/CA2003/000335
Publication Date: 18.09.2003 International Filing Date: 11.03.2003
IPC:
A61K 31/192 (2006.01), A61K 31/216 (2006.01)
Applicants: ZAHRADKA, Peter, [CA/CA]; (CA).
TAYLOR,, Carla [CA/CA]; (CA)
Inventors: ZAHRADKA, Peter,; (CA).
TAYLOR,, Carla; (CA)
Agent: ADE & COMPANY; 1700-360 Main Street Winnipeg, Manitoba R3C 3Z3 (CA)
Priority Data:
60/362,243 11.03.2002 US
Title (EN) USE OF PPAR ALPHA AGONISTS FOR THE TREATMENT OF VASCULAR AND RENAL DISEASES
(FR) UTILISATION D'AGONISTES DE PPAR ALPHA DANS LE TRAITEMENT DE MALADIES VASCULAIRES ET RENALES
Abstract: front page image
(EN)Activation of peroxisome proliferator activated receptor alpha (PPAR&agr;) by administration of therapeutic amounts of a PPAR&agr; agonist, WY-14643, inhibits the proliferation of vascular smooth muscle cells, hepatoma cells and human renal proximal tubule cells. WY-14643 may be applicable as a medicament for the treatment of proliferative vascular disease (atherosclerosis, hypertension), revascularization-induced injury (restenosis) and chronic renal failure.
(FR)L'invention concerne l'activation du récepteur alpha activé par les proliférateurs de peroxysome (PPAR?) par administration de quantités thérapeutiques d'un agoniste de PPAR?$g(a), WY-14643, inhibant la prolifération de cellules du muscle lisse vasculaire, de cellules hépatomiques et de cellules tubulaires proximales rénales humaines. WY-14643 peut être utilisé comme un médicament destiné au traitement de maladies prolifératives (athérosclérose, hypertension), d'une blessure induite par revascularisation (resténose) et de l'insuffisance rénale chronique.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)