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1. (WO2003074567) INTERNALIZING ANTI-CD74 ANTIBODIES AND METHODS OF USE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/074567    International Application No.:    PCT/GB2003/000890
Publication Date: 12.09.2003 International Filing Date: 03.03.2003
Chapter 2 Demand Filed:    08.09.2003    
IPC:
C07K 16/28 (2006.01)
Applicants: IMMUNOMEDICS, INC. [US/US]; 300 American Road, Morris Plains, NJ 07950 (US).
McCALL, John, Douglas [GB/GB]; (GB) (BB, MG only)
Inventors: HANSEN, Hans; (US).
LEUNG, Shui-on; (CN).
QU, Zhengxing; (US).
GOLDENBERG, David, M.; (US)
Agent: W.P. Thompson & Co.; Coopers Building, Church Street, Liverpool L1 3AB (GB)
Priority Data:
60/360,259 01.03.2002 US
Title (EN) INTERNALIZING ANTI-CD74 ANTIBODIES AND METHODS OF USE
(FR) INTERNALISATION D'ANTICORPS ANTI-CD74 ET METHODES D'UTILISATION CORRESPONDANTES
Abstract: front page image
(EN)The present invention provides humanized, chimeric and human anti-CD74 antibodies, CD74 antibody fusion proteins, immunoconjugates, vaccines and bispecific that bind to CD74, the major histocompatibility complex (MHC) class-II invariant chain, Ii, which is useful for the treatment and diagnosis of B-cell disorders, such as B-cell malignancies, other malignancies in which the cells are reactive with CD74, and autoimmune diseases, and methods of treatment and diagnosis.
(FR)La présente invention concerne des anticorps anti-CD74 humanisés, chimériques et humains, des protéines de fusion d'anticorps CD74, des immunoconjugués, des vaccins et des anticorps bispécifiques se liant à CD74, la chaîne invariante du complexe majeur d'histocompatibilité (MHC) de classe II, Ii, qui est utile pour le traitement et le diagnostic de troubles associés aux cellules B, tels que les tumeurs malignes des cellules B, les autres tumeurs malignes dans lesquelles les cellules réagissent avec CD74, ainsi que les maladies auto-immunes. L'invention concerne également des méthodes de traitement et de diagnostic.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)