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1. (WO2003074522) PROCESS FOR PREPARING 3-(2-(4-(6-FLUOROBENZO(D) ISOXAZOL-3-YL)-PIPERIDIN-1YL)-ETHYL)-2-METHYL-6,7,8,9-TETRAHYDRO-4H-PYRIDO-(1,2-A) PYRIMIDIN-4-ONE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/074522    International Application No.:    PCT/EP2003/002157
Publication Date: 12.09.2003 International Filing Date: 03.03.2003
Chapter 2 Demand Filed:    25.06.2003    
IPC:
C07D 471/04 (2006.01)
Applicants: FERRER INTERNACIONAL, S.A. [ES/ES]; Gran Via Carlos III, 94, E-08028 Barcelona (ES) (For All Designated States Except US).
FOGUET, Rafael [ES/ES]; (ES) (For US Only).
RAMENTOL, Jorge [ES/ES]; (ES) (For US Only).
FERNANDEZ-CANO, Diego [ES/ES]; (ES) (For US Only).
ARMENGOL, Miguel, P. [ES/ES]; (ES) (For US Only).
CAMPS, Francesc, X. [ES/ES]; (ES) (For US Only).
SALLARES, Juan [ES/ES]; (ES) (For US Only).
PETSCHEN, Inés [ES/ES]; (ES) (For US Only).
PASTO, Mireia [ES/ES]; (ES) (For US Only).
GORDO, Esther [ES/ES]; (ES) (For US Only)
Inventors: FOGUET, Rafael; (ES).
RAMENTOL, Jorge; (ES).
FERNANDEZ-CANO, Diego; (ES).
ARMENGOL, Miguel, P.; (ES).
CAMPS, Francesc, X.; (ES).
SALLARES, Juan; (ES).
PETSCHEN, Inés; (ES).
PASTO, Mireia; (ES).
GORDO, Esther; (ES)
Agent: KINZEBACH, Werner; Reitstötter, Kinzebach & Partner (GBR), Patentanwälte. Sternwartstrasse 4, 81679 München (DE)
Priority Data:
ES 200200531 05.03.2002 ES
Title (EN) PROCESS FOR PREPARING 3-(2-(4-(6-FLUOROBENZO(D) ISOXAZOL-3-YL)-PIPERIDIN-1YL)-ETHYL)-2-METHYL-6,7,8,9-TETRAHYDRO-4H-PYRIDO-(1,2-A) PYRIMIDIN-4-ONE
(FR) PROCEDE DE PREPARATION DE 3-(2-(4-(6-FLUOROBENZO(D) ISOXAZOL-3-YL)-PIPERIDIN-1YL)-ETHYL)-2-METHYL-6,7,8,9-TETRAHYDRO-4H-PYRIDO-(1,2-A) PYRIMIDIN-4-ONE
Abstract: front page image
(EN)The process consists in condensing (2-methyl-6,7,8,9-tetrahydro-4H-pyrido-[1,2-a] pyrimidin-3-yl)-acetaldehyde with 6-fluoro-3-piperidinyl)-1,2-benzisoxazole to yield the intermediate enamine, 3-[2-[4-(6-fluoro­benzo[d]isoxazol-3-yl)-piperidin-1-yl]vinyl}-2-methyl­-6,7,8,9-tetrahydro-pyrido [1,2,-a] pyrimidin-4-one followed by reduction of such an enamine.
(FR)Le procédé consiste à condenser du (2-méthyl-6,7,8,9-tétrahydro-4H-pyrido-[1,2-a] pyrimidin-3-yl)-acétaldéhyde avec un 6-fluoro-3-(4-pipéridinyl)-1,2-benzisoxazole pour former une énamine intermédiaire, 3- [2-[4-(6-fluoro-benzo[d]isoxazol-3-yl)-pipéridin-1-yl]vinyl}-2-méthyl-6,7,8,9-tétrahydro-pyrido[1,2,-a] pyrimidin-4-one ; et à réduire ensuite l'énamine obtenue.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)