WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2003073998) LOCAL PRODUCTION AND/OR DELIVERY OF ANTI-CANCER AGENTS BY STROMAL CELL PRECURSORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/073998    International Application No.:    PCT/US2003/006364
Publication Date: 12.09.2003 International Filing Date: 28.02.2003
Chapter 2 Demand Filed:    25.09.2003    
IPC:
C12N 15/09 (2006.01), A61K 35/12 (2006.01), A61K 35/76 (2006.01), A61K 38/19 (2006.01), A61K 38/21 (2006.01), A61K 48/00 (2006.01), A61P 35/00 (2006.01), A61P 35/02 (2006.01), A61P 35/04 (2006.01), C12N 15/864 (2006.01), C12N 5/0775 (2010.01), C12N 5/10 (2006.01)
Applicants: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM [US/US]; 201 West 7th Street, Austin, TX 78701 (US) (For All Designated States Except US).
STUDENY, Matus [SK/SK]; (SK) (For US Only).
ANDREEFF, Michael [DE/US]; (US) (For US Only).
MARINI, Frank, C. [US/US]; (US) (For US Only)
Inventors: STUDENY, Matus; (SK).
ANDREEFF, Michael; (US).
MARINI, Frank, C.; (US)
Agent: LANDRUM, Charles, P.; Fulbright & Jaworski L.L.P., Suite 2400, 600 Congress Avenue, Austin, TX 78701 (US)
Priority Data:
60/361,465 02.03.2002 US
Title (EN) LOCAL PRODUCTION AND/OR DELIVERY OF ANTI-CANCER AGENTS BY STROMAL CELL PRECURSORS
(FR) PRODUCTION ET/OU ADMINISTRATION LOCALE D'AGENTS ANTICANCEREUX PAR DES PRECURSEURS DE CELLULES STROMALES
Abstract: front page image
(EN)The present invention concerns the use of compositions comprising, and methods for making, genetically modified mesenchymal stem cells to treat subjects with hyperproliferative disorders. Certain embodiments allow local delivery of an agent while avoiding systematic delivery of the agent alone. Stromal precursor cells may be used to produce a biological agent locally at tumour sites. The tumor microenvironment, or other proliferation inducing microenvironment, preferentially promotes the engraftment of stromal precursors as compared to other tissues.
(FR)L'invention concerne l'utilisation de compositions comprenant des cellules souches mésenchymateuses génétiquement modifiées destinées à traiter des sujets présentant des troubles hyperprolifératifs, et des procédés de production associés. Certains modes de réalisation permettent une administration locale d'un agent tout en évitant une administration systémique de l'agent seul. Des précurseurs de cellules stromales peuvent servir à produire un agent biologique localement au niveau de sites tumoraux. Le micro-environnement tumoral, ou un autre micro-environnement induisant une prolifération, favorise de préférence la prise de greffe de précurseurs de cellules stromales en comparaison avec d'autres tissus.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)