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1. (WO2003073823) PDPK1s AS MODIFIERS OF THE p53 PATHWAY AND METHODS OF USE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/073823    International Application No.:    PCT/US2003/006138
Publication Date: 12.09.2003 International Filing Date: 28.02.2003
IPC:
C12Q 1/48 (2006.01), C12Q 1/527 (2006.01), G01N 33/50 (2006.01), G01N 33/573 (2006.01), G01N 33/574 (2006.01), G01N 33/68 (2006.01)
Applicants: EXELIXIS, INC. [US/US]; P.O. Box 511, 170 Harbor Way, South San Francisco, CA 94083-0511 (US) (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NE, NL, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW only).
BELVIN, Marcia [US/US]; (US) (For US Only).
FRANCIS-LANG, Helen [GB/US]; (US) (For US Only).
FRIEDMAN, Lori [US/US]; (US) (For US Only).
PLOWMAN, Gregory, D. [US/US]; (US) (For US Only).
HEUER, Timothy, S. [US/US]; (US) (For US Only)
Inventors: BELVIN, Marcia; (US).
FRANCIS-LANG, Helen; (US).
FRIEDMAN, Lori; (US).
PLOWMAN, Gregory, D.; (US).
HEUER, Timothy, S.; (US)
Agent: SHAYESTEH, Laleh; Exelixis, Inc., P.O. Box 511, 170 Harbor Way, South San Francisco, CA 94083-0511 (US)
Priority Data:
60/361,196 01.03.2002 US
Title (EN) PDPK1s AS MODIFIERS OF THE p53 PATHWAY AND METHODS OF USE
(FR) PDPK1 UTILISES EN TANT QUE MODIFICATEURS DE LA VOIE P53 ET PROCEDES D'UTILISATION ASSOCIES
Abstract: front page image
(EN)Human PDPK1 genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of PDPK1 are provided.
(FR)Les gènes PDPK1 humains ont été identifiés comme étant des modulateurs de la voie p53, et constituent donc des cibles thérapeutiques pour des troubles associés à un dysfonctionnement de p53. L'invention concerne également des procédés d'identification de modulateurs de p53, consistant à rechercher des agents modulant l'activité de PDPK1.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)