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1. (WO2003073098) METHOD OF SCREENING PSYCHOTROPIC

Pub. No.:    WO/2003/073098    International Application No.:    PCT/JP2003/002367
Publication Date: Sep 4, 2003 International Filing Date: Feb 28, 2003
IPC: C12N 15/85
G01N 33/50
Applicants: JAPAN SCIENCE AND TECHNOLOGY AGENCY

YAMANOUCHI PHARMACEUTICAL CO., LTD.

MITSUBISHI CHEMICAL CORPORATION

OSUMI, Noriko

INOKUCHI, Kaoru

FUJIWARA, Michio

Inventors: OSUMI, Noriko

INOKUCHI, Kaoru

FUJIWARA, Michio

Title: METHOD OF SCREENING PSYCHOTROPIC
Abstract:
It is intended to provide an animal model appropriately corresponding to human schizophrenia, a method of screening a psychotropic with the use of the animal model, etc. A hetero rat with Pax-6 mutation, which is constructed by deleting Pax6 gene exclusively in one of allele locus and thus shows behavioral disorders similar to the symptom of human schizophrenia, is employed as a schizophrenia model animal. A psychotropic is screened by administering a test substance to the model animal and measuring/evaluating changes in the behavioral disorders similar to the symptom of human schizophrenia. The behavioral disorders exhibited by the model animal include behavioral disorders with worsened sensory gate mechanism, behavioral disorders with insufficient memory retention due to fear, behavioral disorders with lack of sociality, behavioral disorders with loss in fear and behavioral disorders with loss in curiosity, compared with the wild type.