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1. (WO2003072754) CONJUGATES OF LIGAND, LINKER AND CYTOTOXIC AGENT AND RELATED COMPOSITIONS AND METHODS OF USE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/072754    International Application No.:    PCT/US2003/006344
Publication Date: 04.09.2003 International Filing Date: 27.02.2003
Chapter 2 Demand Filed:    25.09.2003    
IPC:
A61K 38/00 (2006.01), A61K 47/48 (2006.01), C07K 14/595 (2006.01)
Applicants: THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; National Institutes of Health, Office of Technology Transfer, Suite 325, 6011 Executive Boulevard, Rockville, MD 20852 (US) (For All Designated States Except US).
TARASOVA, Nadya, I. [RU/US]; (US) (For US Only).
MICHEJDA, Christopher [US/US]; (US) (For US Only).
DYBA, Marcin [PL/US]; (US) (For US Only).
COHRAN, Carolyn [US/US]; (US) (For US Only)
Inventors: TARASOVA, Nadya, I.; (US).
MICHEJDA, Christopher; (US).
DYBA, Marcin; (US).
COHRAN, Carolyn; (US)
Agent: LARCHER, Carol; Leydig, Voit & Mayer, Ltd., Suite 4900, Two Prudential Plaza, 180 North Stetson Avenue, Chicago, IL 60601-6780 (US)
Priority Data:
60/360,543 27.02.2002 US
60/370,189 05.04.2002 US
Title (EN) CONJUGATES OF LIGAND, LINKER AND CYTOTOXIC AGENT AND RELATED COMPOSITIONS AND METHODS OF USE
(FR) CONJUGUES DE LIGAND, ADAPTATEUR ET AGENT CYTOTOXIQUE, COMPOSITIONS ASSOCIEES ET PROCEDES D'UTILISATION RELATIFS
Abstract: front page image
(EN)A conjugate comprising a ligand, a linker, and a cytotoxic agent, in which the linker is FALA, VLALA, ALAL, ALALA, ChaLALA, ChaChaLAL, NalChaLAL or NalLALA; a composition thereof; a method of delivering a cytotoxic agent in a cell-specific manner; and a method of treating cancer in a mammal.
(FR)L'invention concerne un conjugué comprenant un ligand, un adaptateur et un agent cytotoxique, l'adaptateur étant FALA, VLALA, ALAL, ALALA, ChaLALA, ChaChaLAL, NalChaLAL ou NalLALA ; une composition associée ; un procédé d'administration d'un agent cytotoxique d'une manière propre à une cellule ; et un procédé de traitement du cancer chez les mammifères.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)