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1. (WO2003072735) USE OF PEPTIDE-DRUG CONJUGATION TO REDUCE INTER-SUBJECT VARIABILITY OF DRUG SERUM LEVELS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/072735    International Application No.:    PCT/US2003/005527
Publication Date: 04.09.2003 International Filing Date: 24.02.2003
Chapter 2 Demand Filed:    22.09.2003    
IPC:
A61K 47/48 (2006.01)
Applicants: NEW RIVER PHARMACEUTICALS INC. [US/US]; The Governor Tyler, 1902 Downey Street, Radford, VA 24141 (US) (For All Designated States Except US).
PICCARIELLO, Thomas [US/US]; (US) (For US Only).
KIRK, Randal, J. [US/US]; (US) (For US Only)
Inventors: PICCARIELLO, Thomas; (US).
KIRK, Randal, J.; (US)
Agent: PEREZ, Jeffrey, T.; Hunton & Williams, LLP, 1900 K Street, N.W., Suite 1200, Washington, DC, 20006-1109 (US)
Priority Data:
60/358,382 22.02.2002 US
60/362,083 07.03.2002 US
Title (EN) USE OF PEPTIDE-DRUG CONJUGATION TO REDUCE INTER-SUBJECT VARIABILITY OF DRUG SERUM LEVELS
(FR) UTILISATION DE LA CONJUGAISON PEPTIDE-MEDICAMENT POUR DIMINUER LA VARIABILITE ENTRE SUJETS DE NIVEAUX DE SERUM DE MEDICAMENT
Abstract: front page image
(EN)The present invention provides compositions and methods to decrease inter-patient variability particularly with respect to the systemic concentration of a drug. More particularly the invention relates to oral drugs which are conjugated to peptides or related carriers which alter release characteristics as compared to the analogous free drug. Figure (1) illustrates a typical release profile for reference drug v. a peptide conjugate drug of the present invention.
(FR)L'invention concerne des compositions et des procédés permettant de diminuer la variabilité entre des patients, plus spécifiquement par rapport à la concentration systémique d'un médicament. Plus spécifiquement, l'invention concerne des médicaments administrés par voie orale conjugués à des peptides ou des excipients associés qui modifient les caractéristiques de libération en comparaison du médicament libre analogue.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)