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Machine translation
1. (WO2003072711) METHOD OF USING MODIFIED OLIGONUCLEOTIDES FOR HEPATIC DELIVERY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/072711    International Application No.:    PCT/US2003/005066
Publication Date: 04.09.2003 International Filing Date: 21.02.2003
Chapter 2 Demand Filed:    16.09.2003    
IPC:
C12N 15/11 (2006.01), C12N 15/87 (2006.01)
Applicants: ISIS PHARMACEUTICALS, INC. [US/US]; 2292 Faraday Avenue, Carlsbad, CA 92009 (US) (For All Designated States Except US).
COOK, Phillip, Dan [US/US]; (US) (For US Only).
MANOHARAN, Muthiah [US/US]; (US) (For US Only).
BENNETT, Frank, C. [US/US]; (US) (For US Only)
Inventors: COOK, Phillip, Dan; (US).
MANOHARAN, Muthiah; (US).
BENNETT, Frank, C.; (US)
Agent: CHOI, Wendy, A.; Woodcock Washburn LLP, One Libety Place - 46th Floor, Philadelphia, PA 19103 (US)
Priority Data:
10/080,979 22.02.2002 US
Title (EN) METHOD OF USING MODIFIED OLIGONUCLEOTIDES FOR HEPATIC DELIVERY
(FR) PROCEDE D'UTILISATION D'OLIGONUCLEOTIDES MODIFIES POUR L'ADMINISTRATION HEPATIQUE
Abstract: front page image
(EN)A method of modulating the expression of a nucleic acid in the hepatic system of a mammal is disclosed. In addition, a method of preferentially targeting an oligonucleotide to liver cells in a mammal is disclosed. Also, a method of treating an animal having a hepatic disease or disorder associated with a protein encoded by a gene is disclosed. A composition containing an oligonucleotide is disclosed.
(FR)L'invention concerne un procédé de modification de l'expression d'un acide nucléique dans le système hépatique d'un mammifère. L'invention concerne par ailleurs un procédé de ciblage préférentiel d'un oligonucléotide vers les cellules hépatiques d'un mammifère. De plus, l'invention concerne une méthode de traitement d'un animal atteint d'une maladie hépatique ou d'un trouble associé à une protéine codée par un gène. L'invention concerne enfin une composition qui contient un oligonucléotide.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)