WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2003072578) AZABICYCLIC COMPOUNDS WITH ALFA7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/072578    International Application No.:    PCT/US2003/002688
Publication Date: 04.09.2003 International Filing Date: 14.02.2003
Chapter 2 Demand Filed:    12.08.2003    
IPC:
C07D 453/02 (2006.01), C07D 519/00 (2006.01)
Applicants: PHARMACIA & UPJOHN COMPANY [US/US]; 301 Henrietta, Kalamazoo, MI 49001 (US) (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NE, NL, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW only).
JACOBSEN, Eric, Jon [US/US]; (US) (For US Only).
MYERS, Jason, K. [US/US]; (US) (For US Only).
WALKER, Daniel, P. [US/US]; (US) (For US Only).
WISHKA, Donn, G. [US/US]; (US) (For US Only).
REITZ, Steven, C. [US/US]; (US) (For US Only).
PIOTROWSKI, David, W. [US/US]; (US) (For US Only).
ACKER, Brad, A. [US/US]; (US) (For US Only).
GROPPI, Jr. Vincent, E. [US/US]; (US) (For US Only)
Inventors: JACOBSEN, Eric, Jon; (US).
MYERS, Jason, K.; (US).
WALKER, Daniel, P.; (US).
WISHKA, Donn, G.; (US).
REITZ, Steven, C.; (US).
PIOTROWSKI, David, W.; (US).
ACKER, Brad, A.; (US).
GROPPI, Jr. Vincent, E.; (US)
Agent: HOSLEY, Mary, J.; Global Intellectual Property, Pharmacia & Upjohn Compagny, 301 Henrietta Street, Kalamazoo, MI 49001 (US).
PERRY, Robert Edward; Gill, Jennings & Every, Broadgate House, 7 Eldon Street, London EC2M 7LH (GB)
Priority Data:
60/358,146 20.02.2002 US
Title (EN) AZABICYCLIC COMPOUNDS WITH ALFA7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVITY
(FR) COMPOSES AZABICYCLIQUES PRESENTANT UNE ACTIVITE DE RECEPTEURS D'ALFA 7 NICOTINIQUE ACETYLCHOLINE
Abstract: front page image
(EN)The invention provides compounds of Formula I: (1) wherein Azabicyclo is (2) W is a six-membered heterocyclic ring system having 1-2 nitrogen atoms or a 10-membered bicyclic-six-six-fused-ring system having up to two nitrogen atoms within either or both rings, provided that no nitrogen is at a bridge of ten bicyclic-six-six-fused-ring system, and further having 1-2 substituents independently selected from R3. These compounds may be in the form of pharamaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharamaceuticals to treat diseases or conditions in which &agr;7 is known t be involved.
(FR)L'invention concerne des composés correspondant à la formule I: (1) dans laquelle Azabicyclo est (2) W est un système de noyau hétérocyclique à six éléments comprenant 1 à 2 atomes d'hydrogène ou un système à 10 éléments bicycliques à noyaux fusionnés six par six, qui comprend jusqu'à deux atomes d'azote à l'intérieur d'un ou des deux noyaux, à condition qu'un point de dix systèmes de noyaux fusionnés six par six ne contienne pas d'azote, et possédant en outre 1 à 2 substitutifs sélectionnés indépendamment dans R3. Ces composés peuvent avoir la forme de sels ou de compositions pharmaceutiques, se présenter sous la forme énantiomérique pure et sont utiles dans les préparations pharmaceutiques pour traiter les maladies ou états impliquant A7.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)