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Machine translation
1. (WO2003072555) SUBSTITUTED 3-PHENYL-5-ALKOXY-1,3,4-OXADIAZOL-2-ONES, THE PRODUCTION THEREOF AND THEIR USE IN MEDICAMENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/072555    International Application No.:    PCT/EP2003/001484
Publication Date: 04.09.2003 International Filing Date: 14.02.2003
Chapter 2 Demand Filed:    13.09.2003    
IPC:
C07D 271/113 (2006.01)
Applicants: AVENTIS PHARMA DEUTSCHLAND GMBH [DE/DE]; Brüningstrasse 50, 65929 Frankfurt (DE)
Inventors: SCHOENAFINGER, Karl; (DE).
PETRY, Stefan; (DE).
MÜLLER, Günter; (DE).
BAUER, Armin; (DE).
HEUER, Hubert, Otto; (DE)
Priority Data:
102 08 987.6 28.02.2002 DE
Title (DE) SUBSTITUIERTE 3-PHENYL-5-ALKOXY-1,3,4-OXADIAZOL-2-ONE SOWIE IHRE HERSTELLUNG UND VERWENDUNG IN ARZNEISTOFFEN
(EN) SUBSTITUTED 3-PHENYL-5-ALKOXY-1,3,4-OXADIAZOL-2-ONES, THE PRODUCTION THEREOF AND THEIR USE IN MEDICAMENTS
(FR) 3-PHENYL-5-ALCOXY-1,3,4-OXDIAZOL-2-ONES SUBSTITUES, AINSI QUE LEUR PRODUCTION ET LEUR UTILISATION DANS DES MEDICAMENTS
Abstract: front page image
(DE)Es werden substituierte 3-Phenyl-5-alkoxy-1,3,4-oxadiazol-2-one der allgemeinen Formel (I) beschrieben, worin R1 C7-C22-Alkyl; durch C4-C20-Alkoxy, C6-C10-Aryl, C6-C10-Aryloxy oder C4-C12-Alkoxy-C2-C4-Alkoxy substituiertes C2-C4-Alkyl, C7-C20-Alkenyl; 3&bgr;-Cholestan-3-yl oder substituiertes Phenyl; R2, R3,R4 und R5 Wasserstoff, Halogen, Nitro, C1-C4-Alkyl, C1-C9-Alkyloxy, Trifluormethyl, Trifluormethoxy, oder C6-C10-Aryl-C1-C4-Alkyloxy, C6-C10-Aryloxy, C6-C10-Aryl, C3-C8-Cycloalkyl oder O-C3-C8-Cycloalkyl, die substituiert sein können, bedeuten sowie deren Herstellungsverfahren. Die Verbindungen der Formel (I) üben eine hemmende Wirkung auf die pankreatische Lipase aus und können als Wirkstoffe zur Behandlung von Obesitas eingesetzt werden.
(EN)The invention relates to substituted 3-phenyl-5-alkoxy-1,3,4-oxadiazol-2-ones, of general formula (I), wherein R1 represents C7-C22 alkyl, C2-C4 alkyl that is substituted by C4-C20 alkoxy, C6-C10 aryl, C6-C10 aryloxy or C4-C12-alkoxy-C2-C4-alkoxy, and represents C7-C20 alkenyl, 3$g(b)-cholestan-3-yl or substituted phenyl; R2, R3, R4 and R5 represent hydrogen, halogen, nitro, C1-C4 alkyl, C1-C9 alkyloxy, trifluoromethyl, trifluoromethoxy or C6-C10-aryl-C1-C4-alkyloxy, C6-C10 aryloxy, C6-C10 aryl, C3-C8 cycloalkyl or O-C3-C8-cycloalkyl, whereby all of these can be substituted. The invention also relates to methods for producing these compounds. The compounds of formula (I) have an inhibiting effect on the pancreatic lipase and can be used as active substances for treating obesity.
(FR)L'invention concerne des 3-phényl-5-alcoxy-1,3,4-oxadiazol-2-ones de formules générales 1, dans laquelle R1 désigne alkyle C7-C22 ; alkyle C2-C4 substitué par alcoxy C4-C20, aryle C6-C10, aryloxy C6-C10 ou alcoxy C4-C12-alcoxy C2-C4, alkényle C7-C20 ; 3$g(b)-cholestan-3-yle ou phényle substitué ; R2, R3, R4 et R5 désignent hydrogène, halogène, nitro, alkyle C1-C4, alkyloxy C1-C9, trifluorométhyle, trifluorométhoxy, ou aryle C6-C10-aryloxy C1-C4, aryloxy C6-C10, aryle C6-C10, cycloalkyle C3-C8 ou O-cycloalkyle C3-C8, qui peuvent être substitués. L'invention concerne également le procédé de production de ces composés. Les composés de formule 1 exercent un effet inhibiteur sur la lipase pancréatique et peuvent s'utiliser comme principes actifs pour traiter l'obésité.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: German (DE)
Filing Language: German (DE)