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1. (WO2003072536) A PROCESS FOR PREPARING A PHENYLALANINE DERIVATIVE AND INTERMEDIATES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/072536    International Application No.:    PCT/JP2003/002181
Publication Date: 04.09.2003 International Filing Date: 27.02.2003
Chapter 2 Demand Filed:    04.04.2003    
IPC:
C07C 231/02 (2006.01), C07C 233/87 (2006.01), C07F 5/02 (2006.01)
Applicants: TANABE SEIYAKU CO., LTD. [JP/JP]; 2-10, Dosho-machi 3-chome, Chuo-ku Osaka-shi, Osaka 541-8505 (JP) (For All Designated States Except US).
INOUE, Isao [JP/JP]; (JP) (For US Only).
KURODA, Toru [JP/JP]; (JP) (For US Only).
YOSHIOKA, Ryuzo [JP/JP]; (JP) (For US Only)
Inventors: INOUE, Isao; (JP).
KURODA, Toru; (JP).
YOSHIOKA, Ryuzo; (JP)
Agent: AOYAMA, Tamotsu; Aoyama & Partners IMP Building, 3-7, Shiromi 1-chome Chuo-ku Osaka-shi, Osaka 540-0001 (JP)
Priority Data:
2002-052605 28.02.2002 JP
Title (EN) A PROCESS FOR PREPARING A PHENYLALANINE DERIVATIVE AND INTERMEDIATES THEREOF
(FR) PROCEDE DE PREPARATION D'UN DERIVE DE LA PHENYLALANINE, ET D'UN INTERMEDIAIRE
Abstract: front page image
(EN)The present invention provides a process for preparing a novel phenylalanine derivative of the formula (I): wherein X1 is a halogen atom, X2 is a halogen atom, Q is a group of the formula -CH2- or -(CH2)2- and Y is a lower alkyl group, or a pharmaceutically acceptable salt thereof, which has excellent inhibitory effects on &agr;4 integrin-mediated cell adhesion, and an intermediate useful in the process.
(FR)L'invention porte sur un procédé de préparation d'un nouveau dérivé de la phénylalanine de formule (I) dans laquelle: X1 est un atome d'halogène, X2 est un atome d'halogène, Q est un groupe de formule -CH2- or -(CH2)2- et Y est un groupe alkyle inférieur, et d'un de ses sels pharmacocompatibles, qui présentent d'excellents effets inhibiteurs de l'adhésion cellulaire médiée par l'intégrine A4, et sur un intermédiaire utilisé dans ledit procédé.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, KE, KG, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)