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1. (WO2003072107) SUBSTITUTED PYRIMIDINONES AND PYRIMIDINTHIONES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/072107    International Application No.:    PCT/US2003/005394
Publication Date: 04.09.2003 International Filing Date: 20.02.2003
Chapter 2 Demand Filed:    12.08.2003    
IPC:
C07D 239/46 (2006.01), C07D 401/04 (2006.01), C07D 401/14 (2006.01), C07D 403/12 (2006.01), C07D 417/14 (2006.01)
Applicants: PHARMACIA & UPJOHN COMPANY [US/US]; 301 Henrietta Street, Kalamazoo, MI 49001 (US) (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NE, NL, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW only).
FU, Jian-Min [CA/US]; (US) (For US Only).
CORBETT, Jeffrey, W. [US/US]; (US) (For US Only).
ENNIS, Michael, D. [US/US]; (US) (For US Only).
FRANK, Kristine, E. [US/US]; (US) (For US Only).
HOFFMAN, Robert, L. [US/US]; (US) (For US Only).
VERHOEST, Patrick, R. [US/US]; (US) (For US Only)
Inventors: FU, Jian-Min; (US).
CORBETT, Jeffrey, W.; (US).
ENNIS, Michael, D.; (US).
FRANK, Kristine, E.; (US).
HOFFMAN, Robert, L.; (US).
VERHOEST, Patrick, R.; (US)
Agent: ZHANG, Austin, W.; Global Intellectual Property, Pharmacia & Upjohn Company, 301 Henrietta Street, Kalamazoo, MI 49001 (US).
PERRY, Robert, Edward; Gill Jennings & Every, Broadgate House, 7 Eldon Street, Londong EC2M 7LH (GB)
Priority Data:
60/359,164 22.02.2002 US
Title (EN) SUBSTITUTED PYRIMIDINONES AND PYRIMIDINTHIONES
(FR) PYRIMIDINONES ET PYRIMIDINTHIONES SUBSTITUES
Abstract: front page image
(EN)This invention relates to substituted pyrimidinone and pyrimidithione derivatives that bind with high affifnity to CRF1 receptors, including human CRF1 receptors. This invention also relates to methods of using the compounds of the invention to treat a disorder or condition, the treatment of which can be effected or facilitated by antagonizing a CRF receptor, such as CNS disorders or diseases, particularly anxiety disorders, and depression and stress related disorders.
(FR)L'invention concerne de dérivés de pyrimidinone et de pyrimidithione substitués qui se lient avec une affinité élevée à des récepteurs du facteur de libération de corticotropine (CRF1), notamment des récepteurs de CRF1 humain. L'invention concerne également des méthodes d'utilisation des composés de l'invention pour traiter un trouble ou un état dont le traitement peut être effectué ou facilité par antagonisme du récepteur de CRF, tels que des troubles ou des maladies CNS, notamment des états d'anxiété et des troubles associées à la dépression et au stress.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)