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1. (WO2003072031) TREATMENT OF DISEASE BY INDUCING CELL APOPTOSIS

Pub. No.:    WO/2003/072031    International Application No.:    PCT/US2003/005141
Publication Date: Sep 4, 2003 International Filing Date: Feb 21, 2003
IPC: A61K 38/07
C07K 14/47
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
CHOJKIER, Mario
BUCK, Martina
Inventors: CHOJKIER, Mario
BUCK, Martina
Title: TREATMENT OF DISEASE BY INDUCING CELL APOPTOSIS
Abstract:
The present invention relates generally to the treatment and prevention of diseases characterized by excess cell proliferation and/or activation. In particular, the present invention provides compositions and methods to suppress the activation and/or proliferation of various cells. In some preferred embodiments, the present invention provides compositions and methods to suppress the activation and/or proliferation of mesenchymally derived cells (including, but not limited to hepatic stellate cells), as well as cells with abnormal growth characteristics. In some particularly preferred embodiments, the present invention provides compositions and methods to inhibit or eliminate fibrosis. In alternative preferred embodiments, the present invention provides compositions and methods to induce fibrosis. In still further embodiments, the present invention provides methods and compositions to treat and/or prevent cancer.