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1. WO2003066637 - POLYMORPHS OF CLOPIDOGREL HYDROCHLORIDE AND THEIR USE AS ANTITHROMBIC COMPOUNDS

Publication Number WO/2003/066637
Publication Date 14.08.2003
International Application No. PCT/HU2002/000157
International Filing Date 20.12.2002
Chapter 2 Demand Filed 05.09.2003
IPC
C07D 495/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
495Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
CPC
A61P 7/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
C07D 495/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
495Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • EGIS GYÓGYSZERGYÁR RT. [HU]/[HU] (AllExceptUS)
  • KÓTAY NAGY, Péter [HU]/[HU] (UsOnly)
  • BARKÓCZY, József [HU]/[HU] (UsOnly)
  • SIMIG, Gyula [HU]/[HU] (UsOnly)
  • SZENT KIRÁLLYI, Zsuzsa [HU]/[HU] (UsOnly)
  • GREGOR, Tamás [HU]/[HU] (UsOnly)
  • FARKAS, Béla [HU]/[HU] (UsOnly)
  • VERECZKEYNÉ DONÁTH, Györgyi [HU]/[HU] (UsOnly)
  • NAGY, Kálmán [HU]/[HU] (UsOnly)
  • KÖRTVÉLYESSY, Gyuláné [HU]/[HU] (UsOnly)
Inventors
  • KÓTAY NAGY, Péter
  • BARKÓCZY, József
  • SIMIG, Gyula
  • SZENT KIRÁLLYI, Zsuzsa
  • GREGOR, Tamás
  • FARKAS, Béla
  • VERECZKEYNÉ DONÁTH, Györgyi
  • NAGY, Kálmán
  • KÖRTVÉLYESSY, Gyuláné
Agents
  • ADVOPATENT
Priority Data
P 020043806.02.2002HU
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) POLYMORPHS OF CLOPIDOGREL HYDROCHLORIDE AND THEIR USE AS ANTITHROMBIC COMPOUNDS
(FR) POLYMORPHES D'HYDROCHLORURE DE CLOPIDOGREL ET UTILISATION DE CEUX-CI EN TANT QUE COMPOSES ANTITHROMBOTIQUES
Abstract
(EN)
The invention relates to crystalline forms I and II methyl−(S)− (+)−(2−chlorophenyl)−2−(6,7−dihydro−4H−thieno[3,2.c]pyridine−5−yl)−acetate hydrochloride of the Formula (I) and hydrates thereof, a process for the preparation thereof and pharmaceutical compositions containing the same. The new polymorphs according to the invention exhibit blood platelet aggregation inhibiting and antithrombotic effect.
(FR)
L'invention concerne des formes cristallines I et II d'hydrochlorure de méthyl-(S)-(+)-(2-chlorophényl)-2-(6,7-dihydro-4H-thiéno[3,2.c]pyridine-5-yl)-acétate représentées par la formule (I) et des hydrates de ces composés, un procédé permettant de préparer ces composés, et des compositions pharmaceutiques les contenant. Ces nouveaux polymorphes présentent un effet inhibiteur de l'agrégation plaquettaire et antithrombotique.
Also published as
BG108868
BG10886802
HRP20040741A
IS7385
RSP-696/04
YUP-696/04
Latest bibliographic data on file with the International Bureau