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1. (WO2003062447) NUCLEAR-ENVELOPE AND NUCLEAR-LAMINA BINDING CHIMERAS FOR MODULATING GENE EXPRESSION

Pub. No.:    WO/2003/062447    International Application No.:    PCT/US2003/001529
Publication Date: Jul 31, 2003 International Filing Date: Jan 17, 2003
IPC: C12N 15/62
C12N 15/63
C12N 15/82
Applicants: SYNGENTA PARTICIPATIONS AG
SERA, Takashi
Inventors: SERA, Takashi
Title: NUCLEAR-ENVELOPE AND NUCLEAR-LAMINA BINDING CHIMERAS FOR MODULATING GENE EXPRESSION
Abstract:
The present invention is directed to nucleic acid target-specific chimeric proteins comprising a nuclear-envelope and/or nuclear-lamina binding domain and a DNA binding domain. These proteins, as well as the nucleic acids encoding those proteins, can be used in methods to repress or down-regulate expression of selected genes. The DNA binding domains are preferably from naturally-occurring zinc finger proteins (ZFPs) or artificial zinc finger proteins (AZPs). Molecular switch systems for gene regulation are also provided.