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1. (WO2003062435) A METHOD FOR GENERATING ENGINEERED CELLS FOR LOCUS SPECIFIC GENE REGULATION AND ANALYSIS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/062435    International Application No.:    PCT/US2003/001361
Publication Date: 31.07.2003 International Filing Date: 17.01.2003
IPC:
C12N 15/10 (2006.01), C12N 15/90 (2006.01)
Applicants: MORPHOTEK, INC. [US/US]; 210 Welsh Pool Road, Exton, PA 19341 (US) (For All Designated States Except US).
GRASSO, Luigi [US/US]; (US) (For US Only).
KLINE, J., Bradford [US/US]; (US) (For US Only).
NICOLAIDES, Nicholas, C. [US/US]; (US) (For US Only).
SASS, Philip, M. [US/US]; (US) (For US Only)
Inventors: GRASSO, Luigi; (US).
KLINE, J., Bradford; (US).
NICOLAIDES, Nicholas, C.; (US).
SASS, Philip, M.; (US)
Agent: CALDWELL, John, W.; Woodcock Washburn LLP, One Liberty Place, 46th floor, Philadelphia, PA 19103 (US)
Priority Data:
60/349,565 18.01.2002 US
Title (EN) A METHOD FOR GENERATING ENGINEERED CELLS FOR LOCUS SPECIFIC GENE REGULATION AND ANALYSIS
(FR) METHODE DE GENERATION DE CELLULES GENETIQUEMENT MODIFIEES POUR LA REGULATION ET L'ANALYSE DE GENES SPECIFIQUES D'UN LOCUS
Abstract: front page image
(EN)Inhibitors of mismatch repair can be used to generate hypermutable cells and organisms. By inhibiting this process in cells, new cell lines and varieties with novel and useful properties can be prepared more efficiently than by relying on the natural rate of homologous recombination. These methods are useful for generating targeted loci that can alter the expression profiles of target genes as well as tag exons of gene with a reporter marker to facilitate the monitoring of a given gene product when the host is grown under different conditions or exposed to biological and chemical entities.
(FR)Les inhibiteurs de la réparation des appariements peuvent être utilisés pour la génération d'organismes et de cellules hypermutables. Par l'inhibition de ce processus dans les cellules, des nouvelles lignées et variétés cellulaires à propriétés nouvelles et utiles peuvent être préparées plus efficacement que si l'on se repose sur le taux de recombinaison homologue naturel. Lesdites méthodes sont utiles pour la génération de locus ciblés pouvant modifier les profils d'expression de gènes cibles ainsi que d'exons étiquettes d'un gène au moyen d'un marqueur rapporteur pour faciliter le contrôle d'un produit génique donné lorsque l'hôte est cultivé dans différentes conditions ou exposé à des entités biologiques et chimiques.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)