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1. (WO2003062276) MULTIMERS OF RECEPTOR-BINDING LIGANDS

Pub. No.:    WO/2003/062276    International Application No.:    PCT/GB2003/000253
Publication Date: Jul 31, 2003 International Filing Date: Jan 24, 2003
IPC: A61K 38/00
C07K 14/575
C07K 14/61
Applicants: ASTERION LIMITED
ROSS, Richard
ARTYMIUK, Peter
SAYERS, Jon
Inventors: ROSS, Richard
ARTYMIUK, Peter
SAYERS, Jon
Title: MULTIMERS OF RECEPTOR-BINDING LIGANDS
Abstract:
The invention relates to the provision of oligomeric polypeptides (dimers, trimers, etc) comprising the ligand binding domains of cytokines which are linked via flexible polypeptide linker molecules. The linker molecules optionally comprise protease sensitive sites to modulate the release of biologically active cytokines when administered to a human or animal subject.