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1. (WO2003062263) AGGRECANASE-1 AND -2 PEPTIDE SUBSTRATES AND METHODS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/062263    International Application No.:    PCT/US2003/001327
Publication Date: 31.07.2003 International Filing Date: 15.01.2003
Chapter 2 Demand Filed:    04.08.2003    
IPC:
C12N 9/64 (2006.01)
Applicants: ORTHO MC NEIL PHARMACEUTICAL, INC. [US/US]; U.S. Route 202, Raritan, NJ 08869-0602 (US)
Inventors: FOURIE, Anne; (US).
KARLSSON, Lars; (US).
COLES, Fawn; (US)
Agent: JOHNSON, Philip, S.; Johnson & Johnson, One Johnson & Johnson Plaza, New Brunswick, NJ 08933 (US).
McCORMACK, Myra, H.; Johnson & Johnson, One Johnson & Johnson Plaza, New Brunswick, NJ 08933 (US)
Priority Data:
10/050,200 16.01.2002 US
Title (EN) AGGRECANASE-1 AND -2 PEPTIDE SUBSTRATES AND METHODS
(FR) SUBSTRATS PEPTIDIQUES AGGRECANASE-1 ET -2 ET PROCEDES ASSOCIES
Abstract: front page image
(EN)The present invention describes synthetic peptide substrates of the metalloproteases, agggrecanase-1 and/or -2 suitable for assays of enzyme activity. The invention also describes methods using these peptides to discover pharmaceutical agents that modulate these proteases.
(FR)L'invention concerne des substrats peptidiques synthétiques de métalloprotéases, d'aggrécanase-1 et/ou -2 appropriés à des analyses d'activité enzymatique. L'invention concerne également des procédés mettant en oeuvre lesdits peptides afin de découvrir des agents pharmaceutiques qui modulent lesdites protéases.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)