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1. (WO2003061683) PEPTIDES FOR ENHANCING RESISTANCE TO MICROBIAL INFECTIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/061683    International Application No.:    PCT/FI2003/000044
Publication Date: 31.07.2003 International Filing Date: 21.01.2003
Chapter 2 Demand Filed:    07.07.2003    
IPC:
A61K 38/08 (2006.01), A61K 38/12 (2006.01), C07K 7/06 (2006.01), C07K 7/64 (2006.01), C12N 5/00 (2006.01)
Applicants: NAVOLOTSKAYA, Elena, Vital'evna [RU/RU]; (RU).
ZARGAROVA, Tatiana, Alexandrovna [RU/RU]; (RU).
ZAVYALOV, Vladimir, Petrovich [RU/RU]; (RU).
KORPELA, Timo, Kalevi [FI/FI]; (FI)
Inventors: NAVOLOTSKAYA, Elena, Vital'evna; (RU).
ZARGAROVA, Tatiana, Alexandrovna; (RU).
ZAVYALOV, Vladimir, Petrovich; (RU).
KORPELA, Timo, Kalevi; (FI)
Common
Representative:
KORPELA, Timo, Kalevi; Kraatarinkatu 1 D 42, FIN-20610 Turku (FI)
Priority Data:
20020121 23.01.2002 FI
Title (EN) PEPTIDES FOR ENHANCING RESISTANCE TO MICROBIAL INFECTIONS
(FR) PEPTIDES DESTINES A AMELIORER LA RESISTANCE A DES INFECTIONS MICROBIENNES
Abstract: front page image
(EN)The present invention is related to novel bioactive pentapeptides, pentarphins, the main indication of which is enhancing phagocytic activity of macrophages against microbes. In particular, the cyclopentapeptide, cyclo(Val-Lys-Gly-Phe-Tyr), termed cyclopeptarphin, was 100 times more active than tuftsin. Cyclopentarphin was non-toxic even at concentrations 1000 times higher than the minimum active dose, while being non-immunogenic. Furthermore, cyclopentarphin is more stable to enzymatic cleavage in vitro as compared to linear pentarphin and tuftsin and, hence, its life span in vivo is also larger than that of linear peptides. High efficacy and safety of cyclopentarphin enable elaboration of novel drugs that enhance the resistance of human and animal organisms to microbes and micro particles.
(FR)L'invention concerne de nouveaux pentapeptides bioactifs, des pentarphines, l'indication principale desquels étant d'améliorer l'activité phagocytique des macrophages contre les microbes. L'invention concerne plus particulièrement du cyclopentapeptide, cyclo(Val-Lys-Gly-Phe-Tyr), appelé cyclopeptarphine, qui est 100 fois plus actif que la tuftsine. La cyclopentarphine est non toxique même à des concentrations 1000 fois supérieures à la dose active minimum, étant donné qu'elle est non immunogène. En outre, la cyclopentarphine est plus stable au clivage enzymatique <i>in vivo </i>que la pentarphine et la tuftsine linéaire et, de ce fait, sa durée de vie <i>in vivo</i> est plus longue que celle des peptides linéaires. L'efficacité et la sécurité élevées de la cyclopentarphine permettent l'élaboration de nouveaux médicaments permettant d'améliorer la résistance des organismes humain et animal aux microbes et aux microparticules.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)