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1. (WO2003061566) ANTI−CANCER COMBINATION AND USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/061566    International Application No.:    PCT/US2002/041767
Publication Date: 31.07.2003 International Filing Date: 31.12.2002
IPC:
A61K 45/06 (2006.01)
Applicants: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM [IL/IL]; Jabotinsky Street 46, 91042 Jerusalem (IL) (For All Designated States Except US).
CHILDREN'S MEDICAL CENTER CORPORATION [US/US]; 300 Longwood Avenue, Boston, MA 02115 (US) (For All Designated States Except US).
BEN-SASSON, Shmuel, A. [IL/IL]; (IL) (For US Only).
TSIRULNIKOV, Lilia [IL/IL]; (IL) (For US Only).
VAINSTEIN, Vladimir [IL/IL]; (IL) (For US Only)
Inventors: BEN-SASSON, Shmuel, A.; (IL).
TSIRULNIKOV, Lilia; (IL).
VAINSTEIN, Vladimir; (IL)
Agent: RESNICK, David, R.; Nixon Peabody LLP, 101 Federal Street, Boston, MA 02110 (US)
Priority Data:
60/351,946 24.01.2002 US
Title (EN) ANTI−CANCER COMBINATION AND USE THEREOF
(FR) COMBINAISON ANTICANCEREUSE ET SON UTILISATION
Abstract: front page image
(EN)The present invention relates to the surprising discovery that the combination of several agents, each well known for its established role in treatinf cancer, inflammation, hemostasis, bone resorption or serving as a solubilizing vehicle, results in a synergistic anti−cancer composition. Furthermore, the combination of at least three agents allows the cytotoxic agent, such as cyclophosphamide, to be used at a lower dosage than when administered alone. One predidted consequence of this treatment, therefore, is a highly desirable reduction in toxic side effects due to the cytotoxic agent.
(FR)L'invention concerne une découverte étonnante, à savoir que la combinaison de plusieurs agents, chacun bien connu pour son rôle établi au niveau du traitement du cancer, des inflammations, de l'hémostase, de la résorption osseuse, ou en tant que véhicule solubilisant, produit une composition synergétique anticancéreuse. En outre, la combinaison d'au moins trois agents permet d'utiliser l'agent cytotoxique, par exemple le cyclophosphamide, à un dosage plus faible que lorsqu'il est administré seul. En conséquence, ce traitement a notamment pour conséquence prévisible une diminution particulièrement recherchée des effets toxiques secondaires dus à l'agent cytotoxique.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)