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1. (WO2003059943) CONFORMATION-SPECIFIC, PROTEIN KINASE BINDING PEPTIDES AND RELATED METHODS AND PRODUCTS

Pub. No.:    WO/2003/059943    International Application No.:    PCT/EP2003/000343
Publication Date: Jul 24, 2003 International Filing Date: Jan 15, 2003
IPC: C07K 7/08
G01N 33/574
Applicants: KARO BIO AB
ASHRAF, Syed, Salman
BALLAS, Lawrence, Michael
HAMILTON, Paul, T.
Inventors: ASHRAF, Syed, Salman
BALLAS, Lawrence, Michael
HAMILTON, Paul, T.
Title: CONFORMATION-SPECIFIC, PROTEIN KINASE BINDING PEPTIDES AND RELATED METHODS AND PRODUCTS
Abstract:
A method is described of identifying peptides which bind to protein kinases, especially a protein kinase C, in (a) an active conformation-specific, (b) an inactive conformation- specific, or (c) an active conformation-independent manner. Peptides which specifically bind PKCα in an active conformation specific manner have been identified , and may be used diagnostically and in other ways.