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Machine translation
1. (WO2003059290) DIAGNOSTIC AND THERAPEUTIC USES OF TOPORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/059290    International Application No.:    PCT/US2003/000761
Publication Date: 24.07.2003 International Filing Date: 09.01.2003
Chapter 2 Demand Filed:    06.08.2003    
IPC:
C07K 14/47 (2006.01), C07K 16/18 (2006.01)
Applicants: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY [US/US]; 335 George Street, Suite 3200, New Brunswick, NJ 08901 (US) (For All Designated States Except US).
RUBIN, Eric, H. [US/US]; (US) (For US Only).
SALEEM, Ahamed [IN/US]; (US) (For US Only).
RASHEED, Zeshaan [US/US]; (US) (For US Only).
HALUSKA, Paul, Jr. [US/US]; (US) (For US Only)
Inventors: RUBIN, Eric, H.; (US).
SALEEM, Ahamed; (US).
RASHEED, Zeshaan; (US).
HALUSKA, Paul, Jr.; (US)
Agent: PERKINS COIE LLP; Michael J. Wise/Lauren Sliger, Patent-LA, P.O. Box 1208, Seattle, WA 98111-1208 (US)
Priority Data:
60/346,953 09.01.2002 US
Title (EN) DIAGNOSTIC AND THERAPEUTIC USES OF TOPORS
(FR) UTILISATION DIAGNOSTIQUE ET THERAPEUTIQUE DE TOPORS
Abstract: front page image
(EN)Topors and topors antibody can be used to manipulate the presence and function of both Top1 and p53 in cells, thus controlling the function of the Top1 and p53 proteins. Topors is implicated in prevention of tumorigenesis through its role in DNA repair and preventing faulty or mutated DNA from replicating. Topors can be used therapeutically as a medicament and topors DNA can be used in gene therapy. Topors antibody may be used to detect the presence of cancer by screening for the absence of topors in a given cell or tissue sample. Kits comprising the topors antibody are also contemplated.
(FR)On peut utiliser des topors et des anticorps topors pour manipuler la présence et la fonction des Top1 et p53 dans les cellules et réguler ainsi la fonction des protéines Top1 et p53. Le topors participe à la prévention de la genèse des tumeurs grâce à son rôle dans la réparation d'ADN et la prévention de la réplication l'ADN erroné ou mutant. Un ADN topors peut être utilisé en thérapie en tant que médicament mais aussi en thérapie génique. L'anticorps topors peut s'utiliser pour détecter la présence du cancer par le criblage visant à détecter l'absence de topors dans une cellule ou un échantillon de tissu donné. L'invention concerne aussi des kits comprenant l'anticorps topors.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)