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Machine translation
1. (WO2003059285) RIP2: A METHOD OF SIGNALING IN THE INNATE AND ADAPTIVE IMMUNE SYSTEMS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/059285    International Application No.:    PCT/US2003/000663
Publication Date: 24.07.2003 International Filing Date: 09.01.2003
IPC:
C12Q 1/48 (2006.01), G01N 33/50 (2006.01), G01N 33/564 (2006.01)
Applicants: YALE UNIVERSITY [US/US]; 451 College Street, New Haven, CT 06520 (US) (For All Designated States Except US).
FLAVELL, Richard, A. [US/US]; (US) (For US Only).
KOBAYASHI, Koichi [JP/US]; (US) (For US Only).
MEDZHITOV, Ruslan, M. [UZ/US]; (US)
Inventors: FLAVELL, Richard, A.; (US).
KOBAYASHI, Koichi; (US).
MEDZHITOV, Ruslan, M.; (US)
Agent: GRANAHAN, Patricia; Ropes & Gray, One International Place, Boston, MA 02110-2624 (US)
Priority Data:
60/348,172 09.01.2002 US
Title (EN) RIP2: A METHOD OF SIGNALING IN THE INNATE AND ADAPTIVE IMMUNE SYSTEMS
(FR) RIP2: MEDIATEUR DE SIGNALEMENT DANS LE SYSTEME IMMUNITAIRE INNE ET DANS LE SYSTEME IMMUNITAIRE ADAPTATIF
Abstract: front page image
(EN)This invention provides a method of identifying a compound that modulates an innate immunce response and an adaptive immune response comprising contacting cells expressing RIP2 with a candidate compound, and determining whether the candidate compound modulates RIP2 activity in the cells, wherein modulation of RIP2 activity in the cells by the candidate compound indicates that the candidate compound modulates the innate immune response and adaptive immune response.
(FR)L'invention concerne une méthode d'identification d'un composé modulant une réponse immunitaire innée et une réponse immunitaire adaptative, consistant à mettre des cellules exprimant RIP2 en contact avec un composé candidat, et à déterminer si ce composé candidat module l'activité de RIP2 dans les cellules, la modulation de l'activité de RIP2 dans les cellules par le biais du composé candidat indiquant que le composé candidat module la réponse immunitaire innée et la réponse immunitaire adaptative.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)