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Machine translation
1. (WO2003059280) EFFICIENT LIPOSOMAL ENCAPSULATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/059280    International Application No.:    PCT/US2003/000377
Publication Date: 24.07.2003 International Filing Date: 08.01.2003
Chapter 2 Demand Filed:    30.07.2003    
IPC:
A61K 9/127 (2006.01), B01J 13/02 (2006.01)
Applicants: ELAN PHARMACEUTICALS, INC. [US/US]; 800 Gateway Boulevard, South San Francisco, CA 94080 (US) (For All Designated States Except US).
LI, Xingong [CN/US]; (US) (For US Only).
TONG, Shangguan [CN/US]; (US) (For US Only).
POLOZOVA, Alla [CA/US]; (US) (For US Only).
MEERS, Paul, R. [US/US]; (US) (For US Only).
PERKINS, Walter, R. [US/US]; (US) (For US Only)
Inventors: LI, Xingong; (US).
TONG, Shangguan; (US).
POLOZOVA, Alla; (US).
MEERS, Paul, R.; (US).
PERKINS, Walter, R.; (US)
Agent: REA, Teresa, Stanek; Burns, Doane, Swecker & Mathis, L.L.P., PO Box 1404, Alexandria, VA 22313-1404 (US)
Priority Data:
60/346,287 09.01.2002 US
Title (EN) EFFICIENT LIPOSOMAL ENCAPSULATION
(FR) ENCAPSULATION EFFICACE DANS UN LIPOSOME
Abstract: front page image
(EN)The present invention concerns a method for preparing liposomes, said method comprising the following steps: (I) mixing at least one liposome-forming lipid, a water-miscible organic solvent and aqueous medium Y to form a gel or liquid containing gel particles without sonication; and thereafter (II) (a) mixing the gel or liquid containing gel particles with aqueous medium Z1 to directly form the liposomes; (b) (i) mixing the gel or liquid containing gel particles with aqueous medium Z1 to form a curd or curdy substance; and (ii) mixing the curd or curdy substance with aqueous medium Z2 to directly form the liposomes; or (c) (i) cooling the gel or liquid containing gel particles to form a waxy substance; and (ii) mixing the waxy substance with aqueous medium Z1 to directly form the liposomes; wherein aqueous media Y, Z1 and Z2 are the same or different.
(FR)La présente invention concerne un procédé de préparation de liposomes consistant à: (I) mélanger au moins un lipide de formation de liposome, un solvant organique hydrosoluble et un milieu aqueux Y afin d'obtenir un gel ou un liquide contenant des particules de gel sans faire appel à la sonication; puis (ii) (a) mélanger le gel ou le liquide contenant des particules de gel avec un milieu aqueux Z1 afin d'obtenir directement des liposomes; (b) (i) mélanger le gel ou le liquide contenant des particules de gel avec un milieu aqueux Z1 afin d'obtenir un caillé ou une substance avec aspect de caillé avec un milieu aqueux Z2 afin d'obtenir directement des liposomes; ou (c) (i) refroidir le gel ou le liquide contenant les particules de gel afin d'obtenir une substance cireuse; et (ii) mélanger la substance cireuse avec le milieu aqueux Z1 afin d'obtenir directement des liposomes; les milieux aqueux Y, Z1 et Z2 étant identiques ou différents.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)