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1. (WO2003059054) TRANSGENIC MOUSE WITH DISRUPTED CALCIUM ION CHANNEL ALPHA1B GENE AND PRODUCTION METHOD THEREOF

Pub. No.:    WO/2003/059054    International Application No.:    PCT/KR2002/000064
Publication Date: Jul 24, 2003 International Filing Date: Jan 15, 2002
IPC: C07K 14/47
C12N 15/85
Applicants: ORIENT CO., LTD
POHANG UNIVERSITY OF SCIENCE AND TECHNOLOGY
SHIN, Hee-Sup
KIM, Chan-Ki
Inventors: SHIN, Hee-Sup
KIM, Chan-Ki
Title: TRANSGENIC MOUSE WITH DISRUPTED CALCIUM ION CHANNEL ALPHA1B GENE AND PRODUCTION METHOD THEREOF
Abstract:
The disclosure concerns knockout mice of disrupting alpha 1B subunit of N-type calcium channel by gene targeting, showing reduced response to mechanical and radiant heat stimuli, production method thereof, and a method for reducing pain by suppressing the function of alpha 1B protein of N-type calcium channel. In addition, alpha 1B knockout mice of the present invention have not N-type channel activity and are useful to screening regulator of pain related to N-type calcium channel.