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1. (WO2003057864) TRANSGENIC PAPP-A NON-HUMAN MAMMALS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/057864    International Application No.:    PCT/US2003/000115
Publication Date: 17.07.2003 International Filing Date: 03.01.2003
IPC:
C07K 14/47 (2006.01), C07K 14/775 (2006.01)
Applicants: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH [US/US]; 200 First Street S.W. Rochester, MN 55905 (US) (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NE, NL, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW only).
CONOVER, Cheryl, A. [US/US]; (US) (For US Only).
VAN DEURSEN, Jan, M., A. [NL/US]; (US) (For US Only)
Inventors: CONOVER, Cheryl, A.; (US).
VAN DEURSEN, Jan, M., A.; (US)
Agent: ELLINGER, Mark, S.; Fish & Richardson P.C., P.A. Suite 3300 60 South Sixth Street Minneapolis, MN 55402 (US)
Priority Data:
60/345,709 04.01.2002 US
Title (EN) TRANSGENIC PAPP-A NON-HUMAN MAMMALS
(FR) MAMMIFERES NON HUMAINS TRANSGENIQUES A PROTEINE PLASMATIQUE A ASSOCIEE A LA GESTATION (PAPP-A)
Abstract: front page image
(EN)The invention provides materials and methods related to a transgenic non-human mammal whose genome comprises a disrupted PAPP-A allele. Methods for making such transgenic non-human mammals, and using them identify and characterize agents that affect conditions related to PAPP-A activity, such as vascular restenosis, atherosclerosis, wound healing, cancer, fibrosis, bone development, fetal development, longevity, and fracture repair, also are provided.
(FR)La présente invention concerne des matériaux et des procédés associés à un mammifère non humain transgénique comportant un allèle PAPP-A. L'invention concerne également des procédés pour la fabrication de tels mammifères non humains transgéniques, et leur utilisation pour identifier et caractériser des agents affectant les conditions associées à l'activité de la PAPP-A, telles que la resténose vasculaire, l'athérosclérose, la cicatrisation, le cancer, la fibrose, le développement osseux, le développement du foetus, et la réparation de fractures.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)