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Machine translation
1. (WO2003057830) COMPOSITIONS AND METHODS FOR HYDROXYLATING EPOTHILONES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/057830    International Application No.:    PCT/US2002/040359
Publication Date: 17.07.2003 International Filing Date: 17.12.2002
Chapter 2 Demand Filed:    19.07.2003    
IPC:
C07K 14/79 (2006.01), C12N 9/02 (2006.01), C12P 17/18 (2006.01)
Applicants: BRISTOL-MYERS SQUIBB COMPANY [US/US]; P. O. Box 4000, Route 206 and Provinceline Road, Princeton, NJ 08543-4000 (US) (For All Designated States Except US).
BASCH, Jonathan David, [US/US]; (US) (For US Only).
CHIANG, Shu-Jen [US/US]; (US) (For US Only).
LIU, Suo-Win [US/US]; (US) (For US Only).
NAYEEM, Akbar [US/US]; (US) (For US Only).
SUN, Yuhua [CN/US]; (US) (For US Only).
LI, You [US/US]; (US) (For US Only)
Inventors: BASCH, Jonathan David,; (US).
CHIANG, Shu-Jen; (US).
LIU, Suo-Win; (US).
NAYEEM, Akbar; (US).
SUN, Yuhua; (US).
LI, You; (US)
Agent: KLEIN, Christopher; Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ 08543-4000 (US)
Priority Data:
60/344,271 26.12.2001 US
Title (EN) COMPOSITIONS AND METHODS FOR HYDROXYLATING EPOTHILONES
(FR) COMPOSITIONS ET METHODES D'HYDROXYLATION D'EPOTHILONES
Abstract: front page image
(EN)Isolated nucleic acid sequences and polypeptides encoded thereby for epothilone B hydroxylase and mutants and variants thereof and a ferredoxin located downstream from the epothilone B hydroxylase gene are provided. Also provided are vectors and cells containing these vectors. In addition, methods for producing recombinant microorganisms, methods for using these recombinant microorganism to produce hydroxyalkyl-bearing epothilones and an epothilone analog produced by a mutant of epothilone B hydroxylase are provided.
(FR)La présente invention concerne des séquences d'acide nucléiques isolées et des polypeptides codés par ces dernières qui produisent de l'épothilone B hydroxylase ainsi que des mutants et des variants de cette dernière et une ferrédoxine située en aval du gène d'épothilone B hydroxylase. Cette invention concerne également des vecteurs et des cellules contenant ces vecteurs; des méthodes de production de micro-organismes de recombinaison, des méthodes d'utilisation de ces micro-organismes de recombinaison pour produire des épothilones porteuses d'un groupe hydroxyalkyle et un analogue d'épothilone produit par un mutant de l'épothilone B hydroxylase.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)