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1. (WO2003057721) SUBSTITUTED AMINO CARBOXAMIDES FOR THE TREATMENT OF ALZHEIMER'S DISEASE

Pub. No.:    WO/2003/057721    International Application No.:    PCT/US2003/000326
Publication Date: Jul 17, 2003 International Filing Date: Jan 6, 2003
IPC: A61K 38/00
C07C 237/06
C07K 5/06
C07K 7/06
Applicants: ELAN PHARMACEUTICALS, INC.
PHARMACIA & UPJOHN COMPANY
JAGODZINSKA, Barbara
WARPEHOSKI, Martha, A.
Inventors: JAGODZINSKA, Barbara
WARPEHOSKI, Martha, A.
Title: SUBSTITUTED AMINO CARBOXAMIDES FOR THE TREATMENT OF ALZHEIMER'S DISEASE
Abstract:
The present invention relates to compounds of formula (I) useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the betasecretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharamaceutical compositions and methods of treatment to reduce A beta peptide formation.