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1. WO2003057687 - METHODS FOR PREPARING DOXORUBICIN DERIVATIVES

Publication Number WO/2003/057687
Publication Date 17.07.2003
International Application No. PCT/US2002/041604
International Filing Date 23.12.2002
IPC
C07H 15/203 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
20Carbocyclic rings
203Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
C12P 19/56 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
44Preparation of O-glycosides, e.g. glucosides
56having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
CPC
C07H 15/203
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
20Carbocyclic rings
203Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
C12P 19/56
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
44Preparation of O-glycosides, e.g. glucosides
56having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
Applicants
  • ALBANY MOLECULAR RESEARCH, INC. [US]/[US] (AllExceptUS)
  • THE UNIVERSITY OF IOWA RESEARCH FOUNDATION [US]/[US] (AllExceptUS)
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US]/[US] (AllExceptUS)
  • ALTREUTER, David, H. [US]/[US] (UsOnly)
  • CLARK, Douglas, S. [US]/[US] (UsOnly)
  • MICHELS, Peter, C. [US]/[US] (UsOnly)
  • RICH, Joseph, O. [US]/[US] (UsOnly)
  • MECKLER, Harold [US]/[US] (UsOnly)
  • DORDICK, Jonathan, S. [US]/[US] (UsOnly)
Inventors
  • ALTREUTER, David, H.
  • CLARK, Douglas, S.
  • MICHELS, Peter, C.
  • RICH, Joseph, O.
  • MECKLER, Harold
  • DORDICK, Jonathan, S.
Agents
  • GOLDMAN, Michael, L.
Priority Data
60/344,27927.12.2001US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHODS FOR PREPARING DOXORUBICIN DERIVATIVES
(FR) PROCEDES PERMETTANT DE PREPARER DES DERIVES DE DOXORUBICINE
Abstract
(EN) The present invetion relates to a process for preparation of a product compound of formula (I), where R1 is an acyl group. The process involves reacting a starting compound of formula (II), with an activated acyl donor compound in the presence of a non-chemically modified lipase, under conditions effective to produce the product compound.
(FR) L'invention concerne un procédé de préparation d'un composé représenté par la formule (I), dans laquelle R1 représente un groupe acyle. Ce procédé consiste à faire réagir un composé de départ représenté par la formule (II) avec un donneur acyle activé en présence d'une lipase n'ayant pas été chimiquement modifiée, dans des conditions qui permettent d'obtenir efficacement le composé selon l'invention.
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