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1. (WO2003057671) BIARYL COMPOUND AND USE THEREOF

Pub. No.:    WO/2003/057671    International Application No.:    PCT/JP2002/013655
Publication Date: Jul 17, 2003 International Filing Date: Dec 26, 2002
IPC: C07D 211/58
C07D 401/06
C07D 401/12
C07D 405/06
Applicants: TAKEDA CHEMICAL INDUSTRIES, LTD.

CHO, Nobuo

ASO, Kazuyoshi

ENDO, Satoshi

KANZAKI, Naoyuki

SASAKI, Satoshi

Inventors: CHO, Nobuo

ASO, Kazuyoshi

ENDO, Satoshi

KANZAKI, Naoyuki

SASAKI, Satoshi

Title: BIARYL COMPOUND AND USE THEREOF
Abstract:
A compound having melanocortin receptor agonistic activity or antagonistic activity. It is a novel biaryl compound represented by the formula (I): (I) [wherein ring A and ring B each represents an optionally further substituted six-membered aromatic ring; X represents -CONR4-, -SO2NR4-, -CH2NR4- (R4 represents hydrogen, an optionally substituted hydrocarbon group, etc.), etc.; Y represents a spacer consisting of 1 to 12 atoms; Z represents -CONR6-, -CO- (R6 represents hydrogen, an optionally substituted hydrocarbon group, or an optionally substituted heterocyclic group), etc.; R1 represents optionally substituted amino, etc.; R2 represents an optionally substituted hydrocarbon group, etc.; R3 represents an optionally substituted hydrocarbon group, etc.; and R5 represents an optionally substituted hydrocarbon group, etc.] or a salt of the compound.