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1. (WO2003057670) INDOLES AS NAALADASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/057670    International Application No.:    PCT/US2002/037617
Publication Date: 17.07.2003 International Filing Date: 19.12.2002
IPC:
C07D 209/42 (2006.01)
Applicants: GUILFORD PHARMACEUTICALS INC. [US/US]; 6611 Tributary Street, Baltimore, MD 21224 (US) (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NE, NL, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW only).
TSUKAMOTO, Takashi [US/US]; (JP) (For US Only).
GRELLA, Brian [US/US]; (US) (For US Only).
MAJER, Pavel [CZ/US]; (US) (For US Only)
Inventors: TSUKAMOTO, Takashi; (JP).
GRELLA, Brian; (US).
MAJER, Pavel; (US)
Agent: BENT, Stephen A.; Foley & Lardner, 3000 K Street, Suite 500, Washington, D.C. 20007-5143 (US)
Priority Data:
60/342,764 28.12.2001 US
Title (EN) INDOLES AS NAALADASE INHIBITORS
(FR) INDOLES EN TANT QU'INHIBITEURS DE L'ENZYME NAALADASE
Abstract: front page image
(EN)This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALAdase levels are altered, effecting neuronal activity, effecting TGF-$g(b) activity, inhibiting angiogenesis, and treating glutamate abnormalities, neuropathy, pain, compulsive disorders, prostate diseases, cancers and glaucoma.
(FR)Cette invention concerne de nouveaux composés, des compositions pharmaceutiques et des kits diagnostiques renfermant ces composés, ainsi que des méthodes d'utilisation de tels composés destinées à inhiber l'activité de l'enzyme NAALADase, à détecter des maladies dans lesquelles les niveaux de NAALADase sont altérés, à activer l'activité neuronale, à activer l'activité TGF-$g(b), à inhiber l'angiogenèse, et à traiter des anomalies liées au glutamate, la neuropathie, la douleur, des troubles compulsifs, des maladies de la prostate, des cancers et des glaucomes.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)