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1. (WO2003057259) INDOCYANINE GREEN (ICG) COMPOSITIONS

Pub. No.:    WO/2003/057259    International Application No.:    PCT/US2002/039613
Publication Date: Jul 17, 2003 International Filing Date: Dec 11, 2002
IPC: A61K 41/00
A61K 49/00
Applicants: AKORN, INC.
Inventors: ALAM, Abu
CHAVAN, Ashok, J.
FLOWER, Robert, W.
Title: INDOCYANINE GREEN (ICG) COMPOSITIONS
Abstract:
Aqueous indocyanine green (ICG) composition exhibiting enhanced stability, as well as enhanced ICG concentration, as compared to presently available ICG products. The composition comprises an aqueous ICG composition comprising ICG at a concentration of at least about 10 mg/ml and an aqueous diluent, wherein the composition is stable for at least 24 hours. Diagnostic and therapeutic methods for using these aqueous compositions are also contemplated, e.g., angiography, dye-enhanced photocoagulation, photodynamic therapy, for a variety of conditions, including Age-Related Macular Degeneration (ARMD), lesions and tumors.