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1. (WO2003057226) USE OF PHOSPHOLIPIDS IN PERITONEAL DIALYSIS

Pub. No.:    WO/2003/057226    International Application No.:    PCT/GB2003/000086
Publication Date: Jul 17, 2003 International Filing Date: Jan 14, 2003
IPC: A61K 31/661
A61K 31/685
A61K 47/10
Applicants: BRITANNIA PHARMACEUTICALS LIMITED
HILLS, Brian, Andrew
WOODCOCK, Derek
THOMPSON, Jim
Inventors: HILLS, Brian, Andrew
WOODCOCK, Derek
THOMPSON, Jim
Title: USE OF PHOSPHOLIPIDS IN PERITONEAL DIALYSIS
Abstract:
The efficiency of ultrafiltration in continuous ambulatory peritoneal dialysis (CAPD) is improved by administering a composition comprising at least one surface active phospholipid (SAPL) in powder form, especially as a mixture of phosphatidyl choline and phosphatidyl glycerol, into the peritoneal cavity before commencing CAPD or between CAPD sessions. The SAPL composition may be introduced during surgery to prepare a patient for CAPD and/or subsequently through the incision for the CAPD catheter, or through the catheter itself, between CAPD sessions when one batch of dialysis fluid has been removed and before a fresh batch is supplied.