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1. (WO2003057133) HERBAL COMPOSITION FOR TREATING VARIOUS DISORDERS INCLUDING PSORIASIS, A PROCESS FOR PREPARATION THEREOF AND METHOD FOR TREATMENT OF SUCH DISORDERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/057133    International Application No.:    PCT/IN2003/000008
Publication Date: 17.07.2003 International Filing Date: 10.01.2003
Chapter 2 Demand Filed:    06.08.2003    
IPC:
A61K 9/06 (2006.01), A61K 9/08 (2006.01), A61K 9/10 (2006.01), A61K 9/20 (2006.01), A61K 9/48 (2006.01), A61K 47/02 (2006.01), A61K 47/10 (2006.01), A61K 47/12 (2006.01), A61K 47/26 (2006.01), A61K 47/32 (2006.01), A61K 47/34 (2006.01), A61K 47/36 (2006.01), A61K 47/38 (2006.01), A61K 47/40 (2006.01), A61K 47/44 (2006.01), A61P 1/04 (2006.01), A61P 11/00 (2006.01), A61P 11/06 (2006.01), A61P 17/00 (2006.01), A61P 17/06 (2006.01), A61P 19/02 (2006.01), A61P 29/00 (2006.01), A61P 37/02 (2006.01), A61P 37/08 (2006.01), A61P 43/00 (2006.01)
Applicants: LUPIN LIMITED [IN/IN]; 159 CST Road, Kalina, Santacruz (East), Mumbai 400 098, Maharashtra (IN) (For All Designated States Except US).
ARORA, Sudershan, K. [US/IN]; (IN) (For US Only).
NARENDAR, Sanganabhatla [IN/IN]; (IN) (For US Only).
SRIVASTAVA, Vandita [IN/IN]; (IN) (For US Only).
SARAF, Dinesh, Balakrishna [IN/IN]; (IN) (For US Only).
GUPTA, Lavleen, Kumar [--/--]; (IN) (For US Only)
Inventors: ARORA, Sudershan, K.; (IN).
NARENDAR, Sanganabhatla; (IN).
SRIVASTAVA, Vandita; (IN).
SARAF, Dinesh, Balakrishna; (IN).
GUPTA, Lavleen, Kumar; (IN)
Agent: SUBRAMANIAM, Hariharan; Subramaniam, Nataraj & Associates, E-556, Greater Kailash-II, New Dehli 110 048 (IN)
Priority Data:
22/MUM/02 10.01.2002 IN
Title (EN) HERBAL COMPOSITION FOR TREATING VARIOUS DISORDERS INCLUDING PSORIASIS, A PROCESS FOR PREPARATION THEREOF AND METHOD FOR TREATMENT OF SUCH DISORDERS
(FR) COMPOSITION A BASE DE PLANTES MEDICINALES PERMETTANT DE TRAITER PLUSIEURS TROUBLES PARMI LESQUELS LE PSORIASIS, PROCEDE DE PREPARATION DE CETTE COMPOSITION ET METHODE PERMETTANT DE TRAITER DE TELS TROUBLES
Abstract: front page image
(EN)The invention provides a novel herbal composition containing the extracts of the leaves and/or stem of Argemone mexicana plant, optionally containing the extracts of the fruits of Cuminum cyminum, which exhibits useful in vitro, in vivo and interesting immunological and pharmacological activities; a process for preparation thereof; and a method of treatment of psoriasis and related immunological and biological disorders by administration of the said novel herbal composition. The useful in vitro, in vivo and interesting immunological and pharmacological activities exhibited by the extracts and fractions of the leaves and/or stem of Argemone mexicana plant include immunosuppression, lymphoproliferation inhibition, cytokine modulation such as IL-2 inhibition, IFNgamma inhibition, IL-10 induction, keratinocyte proliferation inhibition, keratolytic activity, endothelial cell proliferation inhibition, inhibition of cell adhesion molecule expression such as ICAM-1, NEST inhibition, and enzymes inhibition such as p60src Tyrosine kinase, which are known to be involved in anti-psoriatic activity. The novel herbal composition(s) is useful in the treatment of various disorders, such as psoriasis including plaque psoriasis, gutatte psoriasis, pustular psoriasis and psoriasis of the nails; dermatitis and scleroderma; eczema; inflammatory disorders and other autoimmune diseases like psoriatic arthritis, rheumatoid arthritis, Crohn's disease, multiple sclerosis, irritable bowel disease, ankylosing spondilitis, systemic lupus erythremetosus and Sjogren's syndrome; allergies like asthma and chronic obstructive pulmonary disease and is safe, well-tolerated, non-toxic, with minimal and reversible adverse reactions or side effects, and most importantly, with minimal relapse or recurrence of the disease following completion of a treatment regimen. The invention also describes the presence of phosphodiesterase (III, IV and V) inhibition and 5-Lipoxygenase inhibition in the aqueous, ethanolic or aqueous-ethanolic extracts of fruits of Cuminum cyminum plant.
(FR)La présente invention concerne une nouvelle composition à base de plantes médicinales contenant des extraits de feuilles et/ou de pédoncules d'Argemone mexicana, éventuellement des extraits de fruits de Cuminum cyminum, laquelle composition présente des activités in vitro et in vivo utiles ainsi que des activités immunologiques et pharmacologiques intéressantes. L'invention concerne également un procédé permettant de préparer cette composition, et une méthode permettant de traiter le psoriasis ainsi que les troubles immunologiques et biologiques qui lui sont associés, par administration de la composition à base de plantes médicinales. Les activités in vivo et vitro et les activités immunologiques et pharmacologiques intéressantes présentées par ces extraits et fragments de feuilles et/ou de pédoncules d'Argemone mexicana comprennent l'immunosuppression, l'inhibition de la lymphoprolifération, la modulation de la cytokine, telle que l'inhibition de IL-2, l'inhibition de IFNgamma, l'induction de IL-10, l'inhibition de la prolifération des kératinocytes, l'activité kératolytique, l'inhibition de la prolifération des cellules endothéliales, l'inhibition de l'expression moléculaire par adhésion de cellules, telles que ICAM-1, l'inhibition de MEST, et l'inhibition d'enzymes telles que la p60src tyrosine kinase, enzymes connues pour être impliquées dans l'activité anti-psoriasique. La ou les nouvelles compositions à base de plantes médicinales sont utilises pour le traitement de divers troubles, tels que le psoriasis, y compris le psoriasis vulgaire, le psoriasis en gouttes, le psoriasis pustuleux et le psoriasis des ongles; la dermite et la sclérodermie; l'eczéma; des troubles inflammatoires et d'autres maladies auto-immunes, telles que l'arthrite psoriasique l'arthrite rhumatoïde, la maladie de Crohn, la sclérose en plaques, le syndrome du colon irritable, la spondylarthrite ankylosante, le lupus érythémateux disséminé et le syndrome de Sjogren; des allergies, telles que l'asthme et une maladie pulmonaire obstructive chronique. En outre, la ou les compositions sont fiables, bien tolérées, non toxiques; elles ont des effets indésirables ou des effets secondaires minimes et réversibles, et plus important encore, elles permettent une faible récidive ou récurrence de la maladie après régime de traitement. La présente invention concerne également l'inhibition des phosphodiestérases ((III, IV et V) et des 5-Lipoxygénases dans les extraits aqueux, éthanoliques ou aqueux-éthanoliques des fruits du Cuminum cyminum.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PT, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)