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1. (WO2003057007) SYSTEM FOR MONITORING BACTERIAL TUMOR TREATMENT

Pub. No.:    WO/2003/057007    International Application No.:    PCT/US2002/041822
Publication Date: Jul 17, 2003 International Filing Date: Dec 31, 2002
IPC: A61B 1/00
A61K 31/198
A61K 38/00
A61K 38/43
A61K 49/00
A61P 35/00
A61P 43/00
C12Q 1/00
C12Q 1/37
G01N 21/00
G01N 21/75
G01N 21/76
G01N 33/00
G01N 33/48
G01N 33/53
G01N 33/554
G01N 33/569
G01N 33/574
Applicants: ANTICANCER, INC.
Inventors: ZHAO, Ming, M.D., Ph.D.
LI, Xiao-Ming, M.D., Ph.D.
YANG, Meng, M.D., Ph.D.
XU, Mingxu, M.D.
JIANG, Ping, M.D.
LI, Linga, M.D.
Title: SYSTEM FOR MONITORING BACTERIAL TUMOR TREATMENT
Abstract:
A method to follow the progress of tumor treatment in subjects utilizes bacteria that have been modified to express a fluorescent protein. The method can also monitor expression of genes associated with the bacteria that produce therapeutic agents during the course of treatment, optionally against a background of fluorescence generated by the tumor itself. The method permits visualization of the progress of treatment in live subjects so that treatments can be modified according to their efficacy.