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1. (WO2003056301) A NOVEL SCREENING METHOD FOR MOLECULAR ANTAGONIST USING FLOW-CYTOMETRY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/056301    International Application No.:    PCT/US2002/040335
Publication Date: 10.07.2003 International Filing Date: 18.12.2002
IPC:
G01N 33/543 (2006.01), G01N 33/68 (2006.01)
Applicants: CENTOCOR, INC. [US/US]; 200 Great Valley Parkway, Malvern, PA 19355 (US)
Inventors: PERITT, David; (US).
SEIDEMAN, David; (US)
Agent: JOHNSON, Philip, S.; One Johnson & Johnson Plaza, New Brunswick, NJ 08933 (US)
Priority Data:
60/341,748 21.12.2001 US
Title (EN) A NOVEL SCREENING METHOD FOR MOLECULAR ANTAGONIST USING FLOW-CYTOMETRY
(FR) PROCEDE DE CRIBLAGE POUR ANTAGONISTE MOLECULAIRE PAR CYTOMETRIE DE FLUX
Abstract: front page image
(EN)The present invention relates to a robust and sensitive assay system utilizing synthetic spherical structures in place of cells for a FACS analysis. The method and system detects the affinity and neutralization activity of a biological molecule without interference from growth medium or cell supernatants. The systems associated with these methods allow high-throughput screening of assays for, in particular, neutralizing monoclonal antibodies.
(FR)la présente invention concerne un système d'analyse fiable et sensible reposant sur l'emploi, pour l'analyse par cytométrie de flux, de structures sphériques synthétiques à la place de cellules. Ce procédé et ce système permettent de détecter l'affinité et l'activité de neutralisation d'une molécule biologique sans interférence de la part d'un support de croissance ou d'un surnageant cellulaire. Les systèmes associés à ces procédés rendent possible un criblage à fort rendement d'essais et permettent en particulier de neutraliser des anticorps monoclonaux.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)