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1. (WO2003055902) INTERMEDIATES FOR LHRH ANTAGONIST SYNTHESIS, PROCESS FOR THEIR PRODUCTION, AND PROCESS FOR LHRH ANTAGONIST PRODUCTION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2003/055902    International Application No.:    PCT/IB2002/005583
Publication Date: 10.07.2003 International Filing Date: 23.12.2002
Chapter 2 Demand Filed:    07.07.2003    
IPC:
C07K 5/08 (2006.01), C07K 5/087 (2006.01), C07K 7/23 (2006.01)
Applicants: POLYPEPTIDE LABORATORIES A/S [DK/DK]; Herredsvejen 2 DK-3400 Hilleröd (DK) (For All Designated States Except US).
RASMUSSEN, Jon, H. [DK/DK]; (DK) (For US Only).
RASMUSSEN, Palle, H. [DK/DK]; (DK) (For US Only).
WACHS, Wolfgang, O. [DE/DE]; (DE) (For US Only).
HANSEN, Stefan [DK/DK]; (DK) (For US Only).
FOMSGAARD, Jens [DK/DK]; (DK) (For US Only)
Inventors: RASMUSSEN, Jon, H.; (DK).
RASMUSSEN, Palle, H.; (DK).
WACHS, Wolfgang, O.; (DE).
HANSEN, Stefan; (DK).
FOMSGAARD, Jens; (DK)
Common
Representative:
FOMSGAARD, Jens; PolyPeptide Laboratories A/S, Herredsvejen 2, DK-3400 Hilleröd (DK)
Priority Data:
0104463-5 29.12.2001 SE
Title (EN) INTERMEDIATES FOR LHRH ANTAGONIST SYNTHESIS, PROCESS FOR THEIR PRODUCTION, AND PROCESS FOR LHRH ANTAGONIST PRODUCTION
(FR) INTERMEDIAIRES DE SYNTHESE D'ANTAGONISTES DE LA GONADOLIBERINE ET LEUR PROCEDE DE PRODUCTION, ET PROCEDE DE PRODUCTION D'ANTAGONISTES DE LADITE GONADOLIBERINE
Abstract: front page image
(EN)The novel tripeptides Ac-D-2Nal-D-4ClPh-D-3Pal-OH and Boc-D-2Nal-D-4ClPhe-D-3Pal-OH are intermediates useful in the synthesis of LHRH analogs by coupling with suitable heptapeptides, in particular with the heptapeptides P1-Ser(P2)-NMeTyr(P3)-D-Lys(Nic)-Leu-Lys(iPr,P4)-Pro-D-AlaNH2 and P1-Ser(P2)-NMeTyr(P3)-D-Asn-Leu-Lys(iPr,P4)-Pro-D-AlaNH2.
(FR)Les nouveaux tripeptides Ac-D-2Nal-D-4ClPh-D-3Pal-OH et Boc-D-2Nal-D-4ClPhe-D-3Pal-OH sont des intermédiaires utilisés dans la synthèse d'analogues de la gonadolibérine (LHRH) par couplage avec des heptapeptides appropriés, notamment les heptapeptides P1-Ser(P2)-NMeTyr(P3)-D-Lys(Nic)-Leu-Lys(iPr,P4)-Pro-D-AlaNH2 et P1-Ser(P2)-NMeTyr(P3)-D-Asn-Leu-Lys(iPr,P4)-Pro-D-AlaNH2.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)