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1. (WO2003055884) 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO[4,5-B]INDOLE-1-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE

Pub. No.:    WO/2003/055884    International Application No.:    PCT/FR2002/003979
Publication Date: Jul 10, 2003 International Filing Date: Nov 20, 2002
IPC: C07D 209/42
C07D 487/04
Applicants: SANOFI-SYNTHELABO
BURNIER, Philippe
FROISSANT, Jacques
MARABOUT, Benoît
MARGUET, Frank
PUECH, Frédéric
Inventors: BURNIER, Philippe
FROISSANT, Jacques
MARABOUT, Benoît
MARGUET, Frank
PUECH, Frédéric
Title: 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO[4,5-B]INDOLE-1-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE
Abstract:
The invention concerns compounds of general formula (I), wherein: X represents a hydrogen or halogen atom; R1 represents a hydrogen atom or a (C1-C4)alkyl group; R2 and R3, represent each, independently of each other, a hydrogen atom or a (C1-C4)alkyl group, or R2 and R3 form, with the atom which bears them, a pyrrolidinyl, piperidinyl, morpholinyl or 4-alkylpiperazinyl group; and Het represents a heteroaromatic group of pyridinyl, 1-oxidopyridinyl, quinolinyl, isoquinolinyl, pyrimidinyl, pyrazinyl, pyridazinyl type, the heteroaromatic group may represent one or several halogen atoms and/or one or several (C1-C4)alkyl, (C1-C4)alkoxyl groups; in the form of bases, addition salts to acids, solvates or hydrates. The invention also concerns pharmaceutical compositions containing same, methods for preparing same and synthesis intermediates.